RACK1 is a ribosome scaffold protein for beta-actin mRNA/ZBP1 complex (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• RACK1 is a ribosome scaffold protein for beta-actin mRNA/ZBP1 complex (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1371/journal.pone.0035034 (literal)

Alternative label

• Marcello Ceci 1, Kristy Welshhans 2, Maria Teresa Ciotti 3, Rossella Brandi 1, Chiara Parisi 1, Francesca Paoletti 1, Luana Pistillo 1, Gary J. Bassell 4, Antonino Cattaneo 1-5 (2012)
  RACK1 is a ribosome scaffold protein for beta-actin mRNA/ZBP1 complex
  in PloS one
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Marcello Ceci 1, Kristy Welshhans 2, Maria Teresa Ciotti 3, Rossella Brandi 1, Chiara Parisi 1, Francesca Paoletti 1, Luana Pistillo 1, Gary J. Bassell 4, Antonino Cattaneo 1-5 (literal)

Pagina inizio

• e35034 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 7 (literal)

Rivista

• PloS one (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 European Brain Research Institute (EBRI), Rome, Italy. 2 Department of Biological Sciences, Kent State University, Kent, Ohio, United States of America. 3 Institute of Neurobiology and Molecular Medicine-CNR, Rome, Italy(*). 4 Departments of Cell Biology, Neurology, Emory University School of Medicine, Atlanta, Georgia, United States of America. 5 Scuola Normale Superiore di Pisa, Pisa, Italy. (*) Confluito in IBCN (provvedimento n. 000116 prot. n. 091899 del 21/12/2010) (literal)

Titolo

• RACK1 is a ribosome scaffold protein for beta-actin mRNA/ZBP1 complex (literal)

Abstract

• In neurons, specific mRNAs are transported in a translationally repressed manner along dendrites or axons by transport ribonucleic-protein complexes called RNA granules. ZBP1 is one RNA binding protein present in transport RNPs, where it transports and represses the translation of cotransported mRNAs, including beta-actin mRNA. The release of beta-actin mRNA from ZBP1 and its subsequent translation depends on the phosphorylation of ZBP1 by Src kinase, but little is known about how this process is regulated. Here we demonstrate that the ribosomal-associated protein RACK1, another substrate of Src, binds the beta-actin mRNA/ZBP1 complex on ribosomes and contributes to the release of ?-actin mRNA from ZBP1 and to its translation. We identify the Src binding and phosphorylation site Y246 on RACK1 as the critical site for the binding to the beta-actin mRNA/ZBP1 complex. Based on these results we propose RACK1 as a ribosomal scaffold protein for specific mRNA-RBP complexes to tightly regulate the translation of specific mRNAs. (literal)

Prodotto di

• ex ME.P02.010.001 / Patologie del S.N. e Fattori di Crescita (ME.P02.010.004) (Modulo)

Autore CNR

• MARIA TERESA CIOTTI (Persona)

Incoming links:

Autore CNR di

• MARIA TERESA CIOTTI (Persona)

Prodotto

• ex ME.P02.010.001 / Patologie del S.N. e Fattori di Crescita (ME.P02.010.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• PloS one (Rivista)