Use of cyclodextrins in the capillary electrophoretic separation of erythro- and threo-mefloquine enantiomers (Articolo in rivista)

Type
Label
  • Use of cyclodextrins in the capillary electrophoretic separation of erythro- and threo-mefloquine enantiomers (Articolo in rivista) (literal)
Anno
  • 1996-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/0021-9673(96)00383-4 (literal)
Alternative label
  • FANALI S, CAMERA E (1996)
    Use of cyclodextrins in the capillary electrophoretic separation of erythro- and threo-mefloquine enantiomers
    in Journal of chromatography (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • FANALI S, CAMERA E (literal)
Pagina inizio
  • 17 (literal)
Pagina fine
  • 23 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 745 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • IMC-CNR (literal)
Titolo
  • Use of cyclodextrins in the capillary electrophoretic separation of erythro- and threo-mefloquine enantiomers (literal)
Abstract
  • Capillary zone electrophoresis has been used for the enantiomer separation of mefloquine diastereaisomers and enantiomers using a background electrolyte at acidic pH supplemented with ?-cyclodextrin derivatives as chiral selectors. The cyclodextrin type and concentration strongly influenced the chiral resolution and among the cyclodextrins used (?-cycle dextrin, dimethylated-, trimethylated- and carboxymethylated-?-cyclodextrin), 2,6,-di-O-methyl-?-cyclodextrin allowed to obtain very good resolution for all the studied optical isomers even at very low concentration. The optimized electrophoretic method resulted to be very reproducible for both migration time and peak areas (STD%<=1%) with a good detection limit (1ยท10-6 M gave a signal to noise ratio=3 for each enantiomer). The analysis of a pharmaceutical preparation did not reveal the presence of the three isomers but only the acemic erythro-mefloquine. Method recovery values, performed on a pharmaceutical preparation, were found in the range 99-102%. (literal)
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