Self-assembled gellan-based nanohydrogels as a tool for prednisolone delivery (Articolo in rivista)

Type
Label
  • Self-assembled gellan-based nanohydrogels as a tool for prednisolone delivery (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1039/c2sm26178b (literal)
Alternative label
  • G. D'Arrigo, C. Di Meo, E. Gaucci, S. Chichiarelli, T. Coviello,D. Capitani, F. Alhaique, P. Matricardi (2012)
    Self-assembled gellan-based nanohydrogels as a tool for prednisolone delivery
    in Soft matter (Print); The Royal Society of Chemistry, Cambridge (Regno Unito)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • G. D'Arrigo, C. Di Meo, E. Gaucci, S. Chichiarelli, T. Coviello,D. Capitani, F. Alhaique, P. Matricardi (literal)
Pagina inizio
  • 11557 (literal)
Pagina fine
  • 11564 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 8 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 8 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 45 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma Dipartimento di Scienze Biochimiche, Sapienza Università di Roma Istituto di Metodologie Chimiche CNR (literal)
Titolo
  • Self-assembled gellan-based nanohydrogels as a tool for prednisolone delivery (literal)
Abstract
  • Self-assembled nanohydrogels based on hydrophobically modified polysaccharides have been extensively studied due to their wide potential applications as drug delivery systems. In the present study, we developed and characterized self-assembling nanohydrogels based on sonicated gellan gum chains. Prednisolone (Pred), a poorly water soluble anti-inflammatory drug, was chemically conjugated to the carboxylic groups of gellan (Ge-Pred) and it was the hydrophobic moiety responsible for the selfassembling process. Ge-Pred was characterized by proton nuclear magnetic resonance spectra (1H-NMR) and the cellular cytotoxicity was assessed by the MTS assay. The self-aggregation behavior in aqueous media of Ge-Pred was evaluated by the pyrene fluorescence technique and the nanohydrogels (NHs), prepared by bath sonication in water, were analyzed by dynamic light scattering (DLS) and z-potential. The average size of the nanohydrogels was about 300 nm and their z-potential values were negative. Our results showed that Ge-Pred NHs are cytocompatible, that the drug is bioavailable and, consequently, they represent an interesting and innovative carrier for prednisolone. (literal)
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