Enantioseparation of venlafaxine and O-desmethylvenlafaxine by capillary electrophoresis with mixed cyclodextrins (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Enantioseparation of venlafaxine and O-desmethylvenlafaxine by capillary electrophoresis with mixed cyclodextrins (Articolo in rivista) (literal)

Anno

• 1999-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/BF02490844 (literal)

Alternative label

• RUDAZ S, VEUTHEY JL, DESIDERIO C, FANALI S (1999)
  Enantioseparation of venlafaxine and O-desmethylvenlafaxine by capillary electrophoresis with mixed cyclodextrins
  in Chromatographia (Wiesb.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• RUDAZ S, VEUTHEY JL, DESIDERIO C, FANALI S (literal)

Pagina inizio

• 369 (literal)

Pagina fine

• 372 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 50 (literal)

Rivista

• Chromatographia (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• University of Geneve; University of Geneve; IMC-CNR; IMC-CNR (literal)

Titolo

• Enantioseparation of venlafaxine and O-desmethylvenlafaxine by capillary electrophoresis with mixed cyclodextrins (literal)

Abstract

• Capillary electrophoresis (CE) has been successfully applied to the separation of the enantiomers of venlafaxine (Vx) and its main active metabolite, O-desmethylvenlafaxine (ODV), by use of a mixture of two cyclodextrins (CDs) added to the background electrolyte (BGE). The use of carboxymethylated ?-cyclodextrin (CMB) enabled the enantioseparation of both Vx and ODV, although separation of all four enantiomers was not achieved. Addition of a second cyclodextrin (?-CD) to the BGE resulted in the simultaneous resolution of the enantiomers of both compounds. In this system, ?-CD enabled discrimination between Vx and ODV whereas CMB enabled the enantioseparation. Resolution was strongly influenced by the ratio of the concentrations of the two complexing agents. Baseline resolution of Vx and ODV was achieved in an uncoated capillary. Addition of organic modifiers to the BGE had a substantial effect on the interaction of the analytes with the ?-CD. (literal)

Prodotto di

• Istituto di metodologie chimiche (IMC) (Istituto)
• Sviluppo di metodologie chimiche avanzate per lo studio di fenomeni delle scienze omiche (PM.P06.019.001) (Modulo)

Autore CNR

• SALVATORE FANALI (Unità di personale interno)
• CLAUDIA DESIDERIO (Unità di personale interno)

Incoming links:

Prodotto

• Istituto di metodologie chimiche (IMC) (Istituto)
• Sviluppo di metodologie chimiche avanzate per lo studio di fenomeni delle scienze omiche (PM.P06.019.001) (Modulo)

Autore CNR di

• SALVATORE FANALI (Unità di personale interno)
• CLAUDIA DESIDERIO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Chromatographia (Rivista)