Bioassay-Guided Isolation of Proanthocyanidins with Antiangiogenic Activities. (Articolo in rivista)

Type
Label
  • Bioassay-Guided Isolation of Proanthocyanidins with Antiangiogenic Activities. (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/np300614u (literal)
Alternative label
  • Pesca MS, Dal Piaz F, Sanogo R, Vassallo A, Bruzual de Abreu M, Rapisarda A, Germanò MP, Certo G, De Falco S, De Tommasi N, Braca A. (2013)
    Bioassay-Guided Isolation of Proanthocyanidins with Antiangiogenic Activities.
    in Journal of natural products (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pesca MS, Dal Piaz F, Sanogo R, Vassallo A, Bruzual de Abreu M, Rapisarda A, Germanò MP, Certo G, De Falco S, De Tommasi N, Braca A. (literal)
Pagina inizio
  • 29 (literal)
Pagina fine
  • 35 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • e pub 2012 /uscita nel 2013 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 76(1 (literal)
Rivista
Note
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • +Dipartimento di Farmacia, Universita degli Studi di Salerno, via Ponte Don Melillo, 84084 Fisciano (SA), Italy ?Departement Medicine Traditionelle, Université de Bamako, INRSP, B.P. 1746, Bamako, Mali §Dipartimento di Scienze, Universita degli Studi della Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy ?Dipartimento di Farmacia, Universita di Pisa, Via Bonanno 33, 56126 Pisa, Italy ?Dipartimento Farmaco-Biologico, Universita di Messina, SS. Annunziata, 98168 Messina, Italy ?Istituto di Genetica e Biofisica \"Adriano Buzzati-Traverso\", 80131 Napoli, Italy (literal)
Titolo
  • Bioassay-Guided Isolation of Proanthocyanidins with Antiangiogenic Activities. (literal)
Abstract
  • The proangiogenic members of the vascular endothelial growth factor (VEGF) family and related receptors play a central role in the modulation of pathological angiogenesis. In order to identify plant compounds able to interfere in the VEGFs/VEGFR-1 (Flt-1) recognition by VEGF family members, the extracts of the aerial parts of Campsiandra guayanensis and Feretia apodanthera were screened by a competitive ELISA-based assay. By using this bioassay-oriented approach five proanthocyanindins, including the new natural compounds (2S)-4',5,7-trihydroxyflavan-(4?->8)-afzelechin (1) and (2S)-4',5,7-trihydroxyflavan-(4?->8)-epiafzelechin (2) and the known geranin B (3), proanthocyanidin A2 (4), and proanthocyanidin A1 (5), were isolated. The study of the antiangiogenic activities of compounds 1-5 using ELISA and SPR assays showed compound 1 as being the most active. The antiangiogenic activity of 1 was also confirmed in vivo by the chicken chorioallantoic membrane assay. Our results indicated 1 as a new antiangiogenic compound inhibiting the interaction between VEGF-A or PlGF and their receptor VEGRF-1. (literal)
Prodotto di
Autore CNR

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it