Effect of Nebulized Beclomethasone on Airway Inflammation and Clinical Status of Children with Allergic Asthma and Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Study (Articolo in rivista)

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  • Effect of Nebulized Beclomethasone on Airway Inflammation and Clinical Status of Children with Allergic Asthma and Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Study (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • Profita M.1, Riccobono L.1, Bonanno A.1, Chanez P.2, Gagliardo R.1, Montalbano A.M.1, Albano G.D.1, 3, Liotta G.1, Gjomarkaj M.1, La Grutta S1. (2012)
    Effect of Nebulized Beclomethasone on Airway Inflammation and Clinical Status of Children with Allergic Asthma and Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Study
    in International archives of allergy and immunology (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Profita M.1, Riccobono L.1, Bonanno A.1, Chanez P.2, Gagliardo R.1, Montalbano A.M.1, Albano G.D.1, 3, Liotta G.1, Gjomarkaj M.1, La Grutta S1. (literal)
Pagina inizio
  • 53 (literal)
Pagina fine
  • 64 (literal)
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  • 14 (literal)
Rivista
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  • 11 (literal)
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  • 161 (literal)
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  • ubMe (literal)
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  • 1 Institute of Biomedicine and Molecular Immunology (IBIM), Unit: \" Ex vivo/In vitro models to study the Immunopathology and the Pharmacology of airway diseases\", Italian National Research Council (CNR), Palermo, Italy. 2 Département des Maladies Respiratoires and INSERM U600, AP-HM, Aix marseille Université Marseille, France. Environmental Health Unit, ARPA Palermo, Italy. 3Dipartimento Biomedico di Medicina, Interna e Specialistica (Di.Bi.M.I.S.), Sezione di Pneumologia, University of Palermo, Palermo, Italy. (literal)
Titolo
  • Effect of Nebulized Beclomethasone on Airway Inflammation and Clinical Status of Children with Allergic Asthma and Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Study (literal)
Abstract
  • We aimed to evaluate the therapeutic effect of nebulized beclomethasone dipropionate (nBDP) on both allergic asthma and rhinitis. In a randomized, double-blind, placebo-controlled study, 40 children (mean age 10.7 ± 2.1 years) with allergic asthma and rhinitis received either nBDP (daily dose of 800 µg, administered twice daily) or placebo for 4 weeks (with a face mask), after a 2-week run-in period of clinical assessment. Nasal and oral fractional exhaled nitric oxide (FeNO) measurements together with pulmonary function tests, nasal and oral exhaled breath condensate (EBC) collection for pH and interleukin-5 (IL-5) measurements as well as nasal and bronchial symptom scores were obtained at baseline and after 4-week treatment. A significant improvement in oral FeNO, oral and nasal EBC IL-5 and nasal EBC pH was observed in the nBDP group when comparing the values with baseline, together with an improvement in symptom score of the visual analogue scale, nasal obstruction, sneezing, rhinorrhea, breathing difficulty, cough, wheezing and sleep disturbance (nBDP end treatment vs. baseline, Wilcoxon signed-rank test). nBDP was more effective than placebo (ANCOVA test) in improving [difference ? = response after treatment at the last visit (active or placebo) - value at baseline] nasal pH, oral IL-5, oral FeNO, forced expiratory volume in 1 s, forced expiratory volume in 1 s/forced vital capacity, peek expiratory flow, visual analogue scale, breathing difficulty, cough, wheezing and sleep disturbance scores. No differences were observed between the nBDP and the placebo group for symptom score of rhinitis. nBDP is a useful treatment for airway inflammation and clinical status in children with concomitant allergic asthma and rhinitis. (literal)
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