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Fat emulsions as diffusive reference standards for tissue simulating phantoms? (Articolo in rivista)

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Fat emulsions as diffusive reference standards for tissue simulating phantoms? (Articolo in rivista) (literal)

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Di Ninni P. [ 1 ] ; Bérubé-Lauzière Y. [ 2 ] ; Mercatelli L. [ 3 ] ; Sani E. [ 3 ] , Martelli F. [ 1 ] (2012)
Fat emulsions as diffusive reference standards for tissue simulating phantoms?
in Applied optics (2004)
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Di Ninni P. [ 1 ] ; Bérubé-Lauzière Y. [ 2 ] ; Mercatelli L. [ 3 ] ; Sani E. [ 3 ] , Martelli F. [ 1 ] (literal)

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[ 1 ] Dipartimento di Fisica e Astronomia dell'Università degli Studi di Firenze, Via G. Sansone 1, Sesto Fiorentino 50019, Firenze, Italy [ 2 ] Département de génie électrique et de génie informatique, Université de Sherbrooke, 2500 boul. Université, Sherbrooke, Québec J1K 2R1, Canada [ 3 ]Institute of Optics, National Council of Research, Largo Fermi 6, Firenze 50125, Italy (literal)

Titolo

Fat emulsions as diffusive reference standards for tissue simulating phantoms? (literal)

Abstract

Intralipid 20% was recently suggested as a diffusive reference standard for tissue simulating phantoms. In this work, we extend previously obtained results to other fat emulsions, specifically Intralipid 10%, Intralipid 30%, Lipovenoes 10%, Lipovenoes 10% PhosphoLipid Reduced, Lipovenoes 20%, Lipofundin S 10%, and Lipofundin S 20%. Of particular importance for practical applications, our measurements carried out at a wavelength of 751 nm show the following features. First, these products show high stability and small batch-to-batch variations in their diffusive optical properties, similar to Intralipid 20%. Second, the absorption coefficient of Intralipid, Lipovenoes, and Lipofundin S are very similar and their measured values are within the experimental errors; moreover the reduced scattering coefficient of Intralipid 20%, Lipovenoes 20%, and Lipofundin S 20% are similar and their measured values are within 5%. Third, the reduced scattering coefficient of Intralipid 10% and Intralipid 30% can be scaled from that of Intralipid 20% with an error of 9% and 2%, respectively. A similar scaling property is valid for Lipovenoes and Lipofundin S. We have verified that this scaling property depends on the composition of the fat emulsions: If the ingredients exactly scale with the concentration then the reduced scattering coefficient almost exactly scale as well. (literal)

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