http://www.cnr.it/ontology/cnr/individuo/prodotto/ID196984

Bioactive long chain N-acylethanolamines in five species of edible bivalve molluscs - Possible implications for mollusc physiology and seafood industry (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Bioactive long chain N-acylethanolamines in five species of edible bivalve molluscs - Possible implications for mollusc physiology and seafood industry (Articolo in rivista) (literal)

Anno

1998-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1016/S0005-2760(97)00132-X (literal)

Alternative label

Sepe N, De Petrocellis L, Montanaro F, Cimino G, Di Marzo V. (1998)
Bioactive long chain N-acylethanolamines in five species of edible bivalve molluscs - Possible implications for mollusc physiology and seafood industry
in Biochimica et biophysica acta. L, Lipids and lipid metabolism; ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, AMSTERDAM (Paesi Bassi)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Sepe N, De Petrocellis L, Montanaro F, Cimino G, Di Marzo V. (literal)

Pagina inizio

101 (literal)

Pagina fine

111 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

1389 (literal)

Rivista

Biochimica et biophysica acta. L, Lipids and lipid metabolism (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

2 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1. CNR, Ist Chim Mol Interesse Biol, I-80072 Arco Felice, Na, Italy 2. CNR, Ist Cibernetica, I-80072 Arco Felice, Na, Italy (literal)

Titolo

Bioactive long chain N-acylethanolamines in five species of edible bivalve molluscs - Possible implications for mollusc physiology and seafood industry (literal)

Abstract

Several long chain N-acylethanolamines, including the proposed endogenous ligands of cannabinoid receptors, anandamide (N-arachidonoylethanolamine, C20:4 NAE) and N-palmitoylethanolamine (C16:0 NAE), as well as some of their putative biosynthetic precursors, the N-acyl-phosphatidylethanolamines, were found in lipid extracts of five species of bivalve molluscs, including Mytilus galloprovincialis, commonly used as sea food. The amounts of these metabolites, the most abundant being C16:0 NAE and N-stearoylethanolamine, appeared to increase considerably when mussels were extracted 24h post-mortem, but were not significantly affected by boiling the tissue prior to extraction. In particulate fractions of homogenates from Mytilus, where the existence of a highly selective cannabinoid receptor with an immunomodulatory function has been previously described, an enzymatic activity capable of catalyzing the hydrolysis of C20:4 NAE amide bond, and displaying similar pH dependency and inhibitor sensitivity profiles as the recently characterized 'fatty acid amide hydrolase' was found. The enzyme K-m and V-max for C20:4 NAE were 29.6 mu M and 73 pmol/mg protein/min, respectively. These findings support the hypothesis that C20:4 NAE, never reported before in the phylum Mollusca, may be a mollusc physiological mediator, and suggest that edible bivalves may be a dietary, albeit limited, source of C16:0 NAE, whose anti-inflammatory properties, when administered orally in amounts higher than those reported here, have been previously reported. (literal)

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