Rapid capillary electrophoretic method for the determination of clozapine and desmethylclozapine in human plasma (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Rapid capillary electrophoretic method for the determination of clozapine and desmethylclozapine in human plasma (Articolo in rivista) (literal)

Anno

• 2001-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/S0021-9673(01)00520- (literal)

Alternative label

• Raggi MA, Bugamelli F, Mandrioli R, Sabbioni C, Volterra V, Fanali S (2001)
  Rapid capillary electrophoretic method for the determination of clozapine and desmethylclozapine in human plasma
  in Journal of chromatography (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Raggi MA, Bugamelli F, Mandrioli R, Sabbioni C, Volterra V, Fanali S (literal)

Pagina inizio

• 289 (literal)

Pagina fine

• 296 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 916 (literal)

Rivista

• Journal of chromatography (Rivista)

Note

• Scopus (literal)
• Pubme (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Univeristà di Bologna; Univeristà di Bologna;Univeristà di Bologna;Univeristà di Bologna;Univeristà di Bologna; IMC-CNR (literal)

Titolo

• Rapid capillary electrophoretic method for the determination of clozapine and desmethylclozapine in human plasma (literal)

Abstract

• A rapid and sensitive high-performance capillary electrophoretic method for the determination of clozapine and its main metabolite desmethylclozapine in human plasma was developed. The separation of the two analytes was carried out in an untreated fused-silica capillary [33 cm (8.5 cm effective length)×50 ?m I.D.] filled with a background electrolyte at pH 2.5 containing ?-cyclodextrin. Baseline separation of clozapine and desmethylclozapine was recorded in less than 3 min. An accurate sample pretreatment by means of solid-phase extraction and subsequent concentration allows for reliable quantitation of clozapine in the plasma of schizophrenic patients under treatment with the drug. The method showed good precision (mean RSD=4.0%) as well as satisfactory extraction yields (~ 88%) and a good sensitivity (limit of quantitation=0.075 ?g ml-1, limit of detection=0.025 ?g ml-1). © 2001 Elsevier Science B.V. (literal)

Prodotto di

• Sviluppo di metodologie chimiche avanzate per lo studio di fenomeni delle scienze omiche (PM.P06.019.001) (Modulo)
• Istituto di metodologie chimiche (IMC) (Istituto)

Autore CNR

• SALVATORE FANALI (Persona)

Incoming links:

Prodotto

• Istituto di metodologie chimiche (IMC) (Istituto)
• Sviluppo di metodologie chimiche avanzate per lo studio di fenomeni delle scienze omiche (PM.P06.019.001) (Modulo)

Autore CNR di

• SALVATORE FANALI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of chromatography (Rivista)