Healing length and bubble formation in DNA (Articolo in rivista)

Type
Label
  • Healing length and bubble formation in DNA (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Rapti, Z; Smerzi, A; Rasmussen, KO; Bishop, AR; Choi, CH; Usheva, A (2006)
    Healing length and bubble formation in DNA
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Rapti, Z; Smerzi, A; Rasmussen, KO; Bishop, AR; Choi, CH; Usheva, A (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 73 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Los Alamos Natl Lab, Ctr Nonlinear Studies, Los Alamos, NM 87545 USA; Univ Illinois, Dept Math, Urbana, IL 61801 USA; Los Alamos Natl Lab, Div Theoret, Los Alamos, NM 87545 USA; Univ Trent, INFM, CNR, BEC, I-38050 Trento, Italy; Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA; Harvard Univ, Sch Med, Boston, MA 02115 USA (literal)
Titolo
  • Healing length and bubble formation in DNA (literal)
Abstract
  • It has been suggested that thermally induced separations ('bubbles') of the DNA double-strand may play a role in the initiation of gene transcription, and an accurate understanding of the sequence dependence of thermal strand separation is therefore desirable. Based on the Peyrard-Bishop-Dauxois model, we show here that the bubble forming ability of DNA can be quantified in terms of a healing length L(n), defined as the length (number of base-pairs) over which a base-pair defect affects bubbles involving n consecutive base-pairs. The probability for a bubble of size n is demonstrated to be proportional to the number of adenine-thymine base-pairs found within this length. The method for calculating bubble probabilities in a given sequence derived from this notion requires several order of magnitude less numerical effort than direct evaluation. (literal)
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