Depressive symptoms, insulin sensitivity and insulin secretion in the RISC cohort study (Articolo in rivista)

Type
Label
  • Depressive symptoms, insulin sensitivity and insulin secretion in the RISC cohort study (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.diabet.2012.09.005 (literal)
Alternative label
  • Bot, M.;Pouwer, F.;De Jonge, P.;Nolan, J.J.;Mari, A.;Hojlund, K.;Golay, A.;Balkau, B.;Dekker, J.M. (2013)
    Depressive symptoms, insulin sensitivity and insulin secretion in the RISC cohort study
    in Diabetes & metabolism (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Bot, M.;Pouwer, F.;De Jonge, P.;Nolan, J.J.;Mari, A.;Hojlund, K.;Golay, A.;Balkau, B.;Dekker, J.M. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.ncbi.nlm.nih.gov/pubmed/23182035 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1, 2: CoRPS - Center of Research on Psychology in Somatic diseases, Department of Medical Psychology and Neuropsychology, Tilburg University, Tilburg, The Netherlands; 3: CoRPS - Center of Research on Psychology in Somatic diseases, Department of Medical Psychology and Neuropsychology, Tilburg University, Tilburg, The Netherlands / Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; 4: Steno Diabetes Center, Copenhagen, Denmark; 5: National Research Council Institute of Biomedical Engineering, Padova, Italy; 6: Diabetes Research Centre, Department of Endocrinology, Odense University Hospital, Odense, Denmark; 7: Service of Therapeutic Education for Chronic Diseases, WHO Collaborating Centre, Department of Community Medicine, University Hospitals of Geneva, Geneva, Switzerland; 8: Inserm, CESP Center for Research in Epidemiology and Population Health, Epidemiology of Diabetes, Obesity and Chronic Kidney Disease Over the Life course, U1018, Villejuif, France / University Paris Sud 11, UMRS 1018, 94807, Villejuif, France; 9: EMGO+ Institute, VU University Medical Center, Amsterdam, The Netherlands (literal)
Titolo
  • Depressive symptoms, insulin sensitivity and insulin secretion in the RISC cohort study (literal)
Abstract
  • AIM: This study explored the association of depressive symptoms with indices of insulin sensitivity and insulin secretion in a cohort of non-diabetic men and women aged 30 to 64 years. METHODS: The study population was derived from the 3-year follow-up of the Relationship between Insulin Sensitivity and Cardiovascular Disease Risk (RISC) study. Presence of significant depressive symptoms was defined as a Center for Epidemiologic Studies Depression Scale (CES-D) score >/= 16. Standard oral glucose tolerance tests were performed. Insulin sensitivity was assessed with the oral glucose insulin sensitivity (OGIS) index. Insulin secretion was estimated using three model-based parameters of insulin secretion (beta-cell glucose sensitivity, the potentiation factor ratio, and beta-cell rate sensitivity). RESULTS: A total of 162 out of 1027 participants (16%) had significant depressive symptoms. Having significant depressive symptoms was not related to either OGIS [standardized beta (beta) -0.033; P=0.24] or beta-cell glucose sensitivity (beta -0.007; P=0.82). Significant depressive symptoms were related to decreased beta-cell rate sensitivity (odds ratio for significant depressive symptoms of the lowest vs. highest quartile of beta-cell rate sensitivity was 2.04; P=0.01). Also, significant depressive symptoms were associated with a statistically significant decrease in the potentiation factor ratio in unadjusted models, but not in the fully adjusted model. CONCLUSION: Depressive symptoms were not related to insulin sensitivity and tended to be weakly associated to some parameters of insulin secretion in non-diabetic individuals. Prospective studies are needed to study the temporal association between depression and insulin secretion. (literal)
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