Molecular Structure, Solution Chemistry and Biological Propierties of the Novel [ImH][trans-IrCl4(Im)(DMSO)], (I) and of the Orange Form of [(DMSO)2H][trans-IrCl4(DMSO)2], (II), Complexes (Articolo in rivista)

Type
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  • Molecular Structure, Solution Chemistry and Biological Propierties of the Novel [ImH][trans-IrCl4(Im)(DMSO)], (I) and of the Orange Form of [(DMSO)2H][trans-IrCl4(DMSO)2], (II), Complexes (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Messori L. 1, Marcon G. 1, Orioli P. 1, Fontani M. 2, Zanello P. 2, Bergamo A. 3, Sava G. 3, Mura P. 4 (2003)
    Molecular Structure, Solution Chemistry and Biological Propierties of the Novel [ImH][trans-IrCl4(Im)(DMSO)], (I) and of the Orange Form of [(DMSO)2H][trans-IrCl4(DMSO)2], (II), Complexes
    in Journal of inorganic biochemistry
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Messori L. 1, Marcon G. 1, Orioli P. 1, Fontani M. 2, Zanello P. 2, Bergamo A. 3, Sava G. 3, Mura P. 4 (literal)
Pagina inizio
  • 37 (literal)
Pagina fine
  • 46 (literal)
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  • Impact Factor of J. of Inorg. Biochem.: 2.204 - 1) Synthesis and X-ray structures: CNR, Istituto di Cristallografia, Sezione di Monterotondo. 2) Solution study and protein binding: Dipartimento di Chimica Università di Firenze. 3) Elettrochemistry: Dipartimento di Chimica, Università di Siena. 4) Cytotoxicity tests: Fondazione Callerio. Trieste (literal)
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  • 95 (literal)
Rivista
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  • Today, ruthenium(III) complexes are of large interest for their potential clinical applications as antitumor and antimetastatic agents. The complex bis(imidazole) tetrachlororuthenate (ICR) developed by B. Keppler has shown very promising antitumor properties on experimental colorectal tumors. Its analogue, NAMI A, with a dimethylsulfoxide ligand in the place of an axial imidazole, is presently undergoing phase I clinical trials owing to its outstanding antimetastatic properties. In spite of the intense investigations, the mechanism of action of antitumor ruthenium(III) complexes is still largely unknown; anyway, sufficient evidence has been collected to state that the mechanism of ruthenium(III) complexes diverges profoundly from that of clinically established anticancer platinum(II) complexes. We are presently considering iridium(III) analogues as a possible alternative to antitumor ruthenium(III) complexes. It is well known that iridium(III) complexes are far more inert than ruthenium(III) complexes, that are, on turn, inert. Thus, our interest in iridium(III) complexes was specifically directed to ascertain the chemical and biological consequences of further reducing the rate of chloride hydrolysis within a series of isostructural metal complexes. (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • 1 Uni Firenze, 2 Uni Siena, 3 Fondazione Callerio, 4 CNR - IC. (literal)
Titolo
  • Molecular Structure, Solution Chemistry and Biological Propierties of the Novel [ImH][trans-IrCl4(Im)(DMSO)], (I) and of the Orange Form of [(DMSO)2H][trans-IrCl4(DMSO)2], (II), Complexes (literal)
Abstract
  • The new iridium(III) complex, imidazolium[trans(DMSO,imidazole)tetrachloroiridate(III)], (I) (DMSO = dimethylsulfoxide), and the orange form of [(DMSO)2H][trans(DMSO)2tetrachloroiridate(III)], (II) have been prepared and characterized, both in the solid state and in solution, by X-ray diffraction and by various physicochemical techniques. Single crystal X-ray diffraction studies point out that complex (II) is isomorphous to the ruthenium(III) analogue, [(DMSO)2H][trans-RuCl4(DMSO)2], (III). Crystallographic data are the following : a = 16.028(2) Å, b = 24.699(3) Å, c = 8.262(1) Å, in space group Pbca (Z = 8) for (imidazolium)[trans(DMSO,imidazole)tetrachloroiridate(III)], (I); and a = 9.189(2) Å, b = 16.511(4) Å, c = 14.028(3) Å, b = 100.82(2)° in space group P2/n (Z = 4) for [(DMSO)2H][trans(DMSO)2tetrachloro iridate(III)], (II). Visible absorption spectra show that both complexes are stable for several days, at pH 7.4, at room temperature. No significant chloride hydrolysis is observed, even at high temperature (70°C), over 24 hours. The extreme stability of these iridium(III) complexes within a physiological buffer was further assessed by 1H NMR; in addition, cyclic voltammetry measurements evidenced a high stability of the oxidation state +3. Preliminary biological studies show that both complexes do not bind appreciably bovine serum albumin nor inhibit significantly the proliferation of representative human tumor cell lines suggesting that hydrolysis of coordinated chlorides is a crucial feature for the biological properties and the antitumor activity of the parent ruthenium(III) complexes. (literal)
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