Mitochondria and ALS: Implications from novel genes and pathways (Articolo in rivista)

Type
Label
  • Mitochondria and ALS: Implications from novel genes and pathways (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • Mauro Cozzolino a b; Alberto Ferri b c; Cristiana Valle b-c; Maria Teresa Carrì b-d (2012)
    Mitochondria and ALS: Implications from novel genes and pathways
    in Molecular and cellular neurosciences (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Mauro Cozzolino a b; Alberto Ferri b c; Cristiana Valle b-c; Maria Teresa Carrì b-d (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • 2012 Jun 15 [Epub ahead of print] (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • a Institute for Translational Pharmacology, CNR, Rome, Italy. b Fondazione Santa Lucia IRCCS, Rome, Italy. c Institute for Cell Biology and Neurobiology, CNR, Rome, Italy. d Department of Biology, University of Rome Tor Vergata, Rome, Italy. (literal)
Titolo
  • Mitochondria and ALS: Implications from novel genes and pathways (literal)
Abstract
  • Evidence from patients with sporadic and familiar amyotrophic lateral sclerosis (ALS) and from models based on the overexpression of mutant SOD1 found in a small subset of patients, clearly point to mitochondrial damage as a relevant facet of this neurodegenerative condition. In this mini-review we provide a brief update on the subject in the light of newly discovered genes (such as TDP-43 and FUS/TLS) associated to familial ALS and of a deeper knowledge of the mechanisms of derangement of mitochondria. This article is part of a Special Issue entitled 'Mitochondrial function'. (literal)
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