FTO genotype is associated with phenotypic variability of body mass index. (Articolo in rivista)

Type
Label
  • FTO genotype is associated with phenotypic variability of body mass index. (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • Yang J, Loos RJ, Powell JE, Medland SE, Speliotes EK, Chasman DI, Rose LM, Thorleifsson G, Steinthorsdottir V, Mägi R, Waite L, Smith AV, Yerges-Armstrong LM, Monda KL, Hadley D, Mahajan A, Li G, Kapur K, Vitart V, Huffman JE, Wang SR, Palmer C, Esko T, Fischer K, Zhao JH, Demirkan A, Isaacs A, Feitosa MF, Luan J, Heard-Costa NL, White C, Jackson AU, Preuss M, Ziegler A, Eriksson J, Kutalik Z, Frau F, Nolte IM, Van Vliet-Ostaptchouk JV, Hottenga JJ, Jacobs KB, Verweij N, Goel A, Medina-Gomez C, Estrada K, Bragg-Gresham JL, Sanna S, Sidore C, Tyrer J, Teumer A, Prokopenko I, Mangino M, Lindgren CM, Assimes TL, Shuldiner AR, Hui J, Beilby JP, McArdle WL, Hall P, Haritunians T, Zgaga L, Kolcic I, Polasek O, Zemunik T, Oostra BA, Junttila MJ, Grönberg H, Schreiber S, Peters A, Hicks AA, Stephens J, Foad NS, Laitinen J, Pouta A, Kaakinen M, Willemsen G, Vink JM, Wild SH, Navis G, Asselbergs FW, Homuth G, John U, Iribarren C, Harris T, Launer L, Gudnason V, O'Connell JR, Boerwinkle E, Cadby G, Palmer LJ, James AL, Musk AW, Ingelsson E, Psaty BM, Beckmann JS, Waeber G, Vollenweider P, Hayward C, Wright AF, Rudan I, Groop LC, Metspalu A, Tee Khaw K, van Duijn CM, Borecki IB, Province MA, Wareham NJ, Tardif JC, Huikuri HV, Cupples LA, Atwood LD, Fox CS, Boehnke M, Collins FS, Mohlke KL, Erdmann J, Schunkert H, Hengstenberg C, Stark K, Lorentzon M, Ohlsson C, Cusi D, Staessen JA, Van der Klauw MM, Pramstaller PP, Kathiresan S, Jolley JD, Ripatti S, Jarvelin MR, de Geus EJ, Boomsma DI, Penninx B, Wilson JF, Campbell H, Chanock SJ, van der Harst P, Hamsten A, Watkins H, Hofman A, Witteman JC, Zillikens MC, Uitterlinden AG, Rivadeneira F, Zillikens MC, Kiemeney LA, Vermeulen SH, Abecasis GR, Schlessinger D, Schipf S, Stumvoll M, Tönjes A, Spector TD, North KE, Lettre G, McCarthy MI, Berndt SI, Heath AC, Madden PA, Nyholt DR, Montgomery GW, Martin NG, McKnight B, Strachan DP, Hill WG, Snieder H, Ridker PM, Thorsteinsdottir U, Stefansson K, Frayling TM, Hirschhorn JN, Goddard ME, Visscher PM. (2012)
    FTO genotype is associated with phenotypic variability of body mass index.
    in Nature
    (literal)
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  • Yang J, Loos RJ, Powell JE, Medland SE, Speliotes EK, Chasman DI, Rose LM, Thorleifsson G, Steinthorsdottir V, Mägi R, Waite L, Smith AV, Yerges-Armstrong LM, Monda KL, Hadley D, Mahajan A, Li G, Kapur K, Vitart V, Huffman JE, Wang SR, Palmer C, Esko T, Fischer K, Zhao JH, Demirkan A, Isaacs A, Feitosa MF, Luan J, Heard-Costa NL, White C, Jackson AU, Preuss M, Ziegler A, Eriksson J, Kutalik Z, Frau F, Nolte IM, Van Vliet-Ostaptchouk JV, Hottenga JJ, Jacobs KB, Verweij N, Goel A, Medina-Gomez C, Estrada K, Bragg-Gresham JL, Sanna S, Sidore C, Tyrer J, Teumer A, Prokopenko I, Mangino M, Lindgren CM, Assimes TL, Shuldiner AR, Hui J, Beilby JP, McArdle WL, Hall P, Haritunians T, Zgaga L, Kolcic I, Polasek O, Zemunik T, Oostra BA, Junttila MJ, Grönberg H, Schreiber S, Peters A, Hicks AA, Stephens J, Foad NS, Laitinen J, Pouta A, Kaakinen M, Willemsen G, Vink JM, Wild SH, Navis G, Asselbergs FW, Homuth G, John U, Iribarren C, Harris T, Launer L, Gudnason V, O'Connell JR, Boerwinkle E, Cadby G, Palmer LJ, James AL, Musk AW, Ingelsson E, Psaty BM, Beckmann JS, Waeber G, Vollenweider P, Hayward C, Wright AF, Rudan I, Groop LC, Metspalu A, Tee Khaw K, van Duijn CM, Borecki IB, Province MA, Wareham NJ, Tardif JC, Huikuri HV, Cupples LA, Atwood LD, Fox CS, Boehnke M, Collins FS, Mohlke KL, Erdmann J, Schunkert H, Hengstenberg C, Stark K, Lorentzon M, Ohlsson C, Cusi D, Staessen JA, Van der Klauw MM, Pramstaller PP, Kathiresan S, Jolley JD, Ripatti S, Jarvelin MR, de Geus EJ, Boomsma DI, Penninx B, Wilson JF, Campbell H, Chanock SJ, van der Harst P, Hamsten A, Watkins H, Hofman A, Witteman JC, Zillikens MC, Uitterlinden AG, Rivadeneira F, Zillikens MC, Kiemeney LA, Vermeulen SH, Abecasis GR, Schlessinger D, Schipf S, Stumvoll M, Tönjes A, Spector TD, North KE, Lettre G, McCarthy MI, Berndt SI, Heath AC, Madden PA, Nyholt DR, Montgomery GW, Martin NG, McKnight B, Strachan DP, Hill WG, Snieder H, Ridker PM, Thorsteinsdottir U, Stefansson K, Frayling TM, Hirschhorn JN, Goddard ME, Visscher PM. (literal)
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  • http://www.nature.com/nature/journal/v490/n7419/full/nature11401.html#/affil-auth (literal)
Rivista
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  • University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia. Jian Yang, Joseph E. Powell & Peter M. Visscher Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006, Australia. Jian Yang, Joseph E. Powell, Sarah E. Medland, Dale R. Nyholt, Grant W. Montgomery, Nicholas G. Martin & Peter M. Visscher MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, UK. Ruth J. F. Loos, Jing Hua Zhao, Jian'an Luan & Nicholas J. Wareham Mount Sinai School of Medicine, New York, New York 10029, USA. Ruth J. F. Loos Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109, USA. Elizabeth K. Speliotes Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA. Elizabeth K. Speliotes Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue, Boston, Massachusetts 02215, USA. Daniel I. Chasman, Lynda M. Rose & Paul M. Ridker Harvard Medical School, Boston, Massachusetts 02215, USA. Daniel I. Chasman & Paul M. Ridker deCODE genetics, IS-101 Reykjavik, Iceland. Gudmar Thorleifsson, Valgerdur Steinthorsdottir, Unnur Thorsteinsdottir & Kari Stefansson Estonian Genome Center, University of Tartu, Tartu 50410, Estonia. Reedik Mägi, Tõnu Esko, Krista Fischer & Andres Metspalu Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. Reedik Mägi, Anubha Mahajan, Anuj Goel, Inga Prokopenko, Cecilia M. Lindgren, Hugh Watkins & Mark I. McCarthy Hudson Alpha Institute for Biotechnology, Huntsville, Alabama 35806, USA. Lindsay Waite Icelandic Heart Association, IS-201 Kopavogur, Iceland. Albert Vernon Smith & Vilmundur Gudnason University of Iceland, IS-101 Reykjavik, Iceland. Albert Vernon Smith & Vilmundur Gudnason Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. Laura M. Yerges-Armstrong, Alan R. Shuldiner & Jeffrey R. O'Connell Department of Epidemiology, The University of North Carolina, Chapel Hill, North Carolina 27514, USA. Keri L. Monda Division of Population Health Sciences & Education, St George's, University of London, London SW17 0RE, UK. David Hadley & David P. Strachan Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98101, USA. Guo Li Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland. Karen Kapur, Zoltán Kutalik & Jacques S. Beckmann Swiss Institute of Bioinformatics, 1005 Lausanne, Switzerland. Karen Kapur & Zoltán Kutalik MRC HGU at the MRC IGMM at the University of Edinburgh, Edinburgh EH8 9AG, UK. Veronique Vitart, Jennifer E. Huffman, Caroline Hayward & Alan F. Wright Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. Sophie R. Wang & Joel N. Hirschhorn Divisions of Genetics and Endocrinology and Program in Genomics, Children's Hospital, Boston, Massachusetts 02115, USA. Sophie R. Wang, Cameron Palmer & Joel N. Hirschhorn Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA. Sophie R. Wang, Cameron Palmer & Joel N. Hirschhorn Department of Epidemiology, Subdivison Genetic Epidemiology, Erasmus MC, Rotterdam, The Netherlands. Ay?e Demirkan, Aaron Isaacs, Ben A. Oostra & Cornelia M. van Duijn Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA. Mary F. Feitosa, Ingrid B. Borecki & Michael A. Province Boston University, Boston, Massachusetts 02118, USA. Nancy L. Heard-Costa, Charles White, L. Adrienne Cupples & Larry D. Atwood Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA. Anne U. Jackson & Michael Boehnke Universität zu Lübeck, Medizinische Klinik II, Ratzeburger Allee 160, 23538 Lübeck, Germany. Michael Preuss, Jeanette Erdmann & Heribert Schunkert Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, 23562 Lübeck, Germany. Michael Preuss & Andreas Ziegler Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden. Joel Eriksson, Mattias Lorentzon & Claes Ohlsson Department of Health Sciences, University of Milano, 20133 Milano, Italy. Francesca Frau & Daniele Cusi Unit of Genetic Epidemiology & Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands. Ilja M. Nolte & Harold Snieder Department of Endocrinology, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands. Jana V. Van Vliet-Ostaptchouk & Melanie M. Van der Klauw LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands. Jana V. Van Vliet-Ostaptchouk, Melanie M. Van der Klauw & Harold Snieder Department of Biological Psychology, VU University, 1081 BT Amsterdam, The Netherlands. Jouke-Jan Hottenga, Gonneke Willemsen, Jacqueline M. Vink, Eco J. C. de Geus & Dorret I. Boomsma Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA. Kevin B. Jacobs Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands. Niek Verweij & Pim van der Harst Cardiovascular Medicine, University of Oxford, Oxford OX3 7BN, UK. Anuj Goel & Hugh Watkins Department of Internal Medicine, Erasmus MC, Rotterdam 3015GE, The Netherlands. Carolina Medina-Gomez, Karol Estrada, M. Carola Zillikens, André G. Uitterlinden, Fernando Rivadeneira & M. Carola Zillikens Department of Epidemiology, Erasmus MC, Rotterdam 3015GE, The Netherlands. Carolina Medina-Gomez, Karol Estrada, Albert Hofman, Jacqueline C. Witteman, André G. Uitterlinden & Fernando Rivadeneira Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), 2300 RC Leiden, The Netherlands. Carolina Medina-Gomez, Karol Estrada, Albert Hofman, Jacqueline C. Witteman, André G. Uitterlinden & Fernando Rivadeneira Biostatistics - Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA. Jennifer Lynn Bragg-Gresham, Carlo Sidore & Goncalo R. Abecasis Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato 09042, Italy. Serena Sanna Dipartimento di Scienze Biomediche, Università di Sassari, 07100 SS, Italy. Carlo Sidore Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK. Jonathan Tyrer Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17487 Greifswald, Germany. Alexander Teumer & Georg Homuth Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7BN, UK. Inga Prokopenko & Mark I. McCarthy Department of Twin Research and Genetic Epidemiology, King's College London, Lambeth Palace Road, London SE1 7EH, UK. Massimo Mangino & Tim D. Spector Department of Medicine, Stanford University School of Medicine, Stanford 94305, California, USA. Themistocles L. Assimes Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland 21201, USA. Alan R. Shuldiner Pathology and Laboratory Medicine, University of Western Australia, Nedlands Western Australia 6009, Australia. Jennie Hui & John P. Beilby Molecular Genetics, PathWest Laboratory Medicine WA, University of Western Australia, Nedlands Western Australia 6009, Australia. Jennie Hui & John P. Beilby School of Population Health, University of Western Australia, Nedlands Western Australia 6009, Australia. Jennie Hui School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK. Wendy L. McArdle Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77 Stockholm, Sweden. Per Hall, Henrik Grönberg & Erik Ingelsson Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA. Talin Haritunians Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh EH16 4TJ, UK. Lina Zgaga, Sarah H. Wild, Igor Rudan, James F. Wilson & Harry Campbell Andrija Stampar School of Public Health, Medical School University of Zagreb, Zagreb, Croatia. Lina Zgaga Faculty of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia. Ivana Kolcic, Ozren Polasek, Tatijana Zemunik & Igor Rudan Institute of Clinical Medicine, Department Of Internal Medicine, University of Oulu, 90014 Oulu, Finland. M. Juhani Junttila & Heikki V. Huikuri Institut für Klinische Molekularbiologie, Christian-Albrechts Universität, 24098 Kiel, Germany. Stefan Schreiber Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany. Annette Peters Munich Heart Alliance, 80802 Munich, Germany. Annette Peters Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy. Andrew A. Hicks Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK. Jonathan Stephens, Nicola S. Foad & Jennifer D. Jolley NHS Blood and Transplant, Cambridge, Cambridge CB2 0PT, UK. Jonathan Stephens, Nicola S. Foad & Jennifer D. Jolley Finnish Institute of Occupational Health, 90220 Oulu, Finland. Jaana Laitinen National Institute for Health and Welfare, 90101 Oulu, Finland. Anneli Pouta & Marjo-Riitta Jarvelin Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, 90014 Oulu, Finland. Anneli Pouta Institute of Health Sciences, Biocenter Oulu, University of Oulu, 90014 Oulu, Finland. Marika Kaakinen & Marjo-Riitta Jarvelin Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands. Gerjan Navis Department of Cardiology, Division Heart & Lungs, University medical Center Utrecht, 3508 GA Utrecht, The Netherlands. Folkert W. Asselbergs Institute of Epidemiology and Social Medicine, University Medicine Greifswald, 17475 Greifswald, Germany. Ulrich John Division of Research, Kaiser Permanente Northern California, Oakland, California 94612, USA. Carlos Iribarren National Institutes on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA. Tamara Harris & Lenore Launer Human Genetics Center and Division of Epidemiology, The University of Texas Health Science Centers, Houston, Texas 77030, USA. Eric Boerwinkle Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario M5G 1L7, Canada. Gemma Cadby & Lyle J. Palmer Medicine and Pharmacology, University of Western Australia, Nedlands Western Australia 6009, Australia. Alan L. James & Arthur W. Musk Pulmonary Physiology, Sir Charles Gairdner Hospital, University of Western Australia, Nedlands Western Australia 6009, Australia. Alan L. James Respiratory Medicine, Sir Charles Gairdner Hospital, University of Western Australia, Nedlands Western Australia 6009, Australia. Arthur W. Musk Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, Washington 98101, USA. Bruce M. Psaty Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101, USA. Bruce M. Psaty Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, 1011 Lausanne, Switzerland. Jacques S. Beckmann Department of Internal Medicine, University Hospital, 1011 Lausanne, Switzerland. Gerard Waeber & Peter Vollenweider Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, 20502 Malmö, Sweden. Leif C. Groop Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK. Kay Tee Khaw Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA. Département de Médecine, Université de Montréal, Montréal, Québec H4J 1C5, Canada. Jean-Claude Tardif & Guillaume Lettre Montreal Heart Institute, Montréal, Québec H1T 1C8, Canada. Jean-Claude Tardif & Guillaume Lettre Framingham Heart Study of the National Heart, Lung, and Blood Institute and Boston University, Framingham, Massachusetts 01702, USA. L. Adrienne Cupples, Caroline S. Fox & Sekar Kathiresan National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Francis S. Collins Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599-7264, USA. Karen L. Mohlke Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Universität zu Lübeck, 23562 Lübeck, Germany. Jeanette Erdmann & Heribert Schunkert Klinik und Poliklinik für Innere Medizin II, 93053 Regensburg, Germany. Christian Hengstenberg & Klaus Stark Department of Cardiovascular Diseases, University of Leuven, 3000 Leuven, Belgium. Jan A. Staessen Department of Epidemiology, Maastricht University, 6200 MD Maastricht, The Netherlands. Jan A. Staessen Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy. Peter P. Pramstaller Department of Neurology, General Central Hospital, 39100 Bolzano, Italy. Peter P. Pramstaller Department of Neurology, University of Lübeck, 23562 Lübeck, Germany. Peter P. Pramstaller Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA. Sekar Kathiresan Center for Human Genetics Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. Sekar Kathiresan Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. Sekar Kathiresan Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA. Sekar Kathiresan Institute for Molecular Medicine Finland, FIMM, University of Helsinki, 00014 Helsinki, Finland. Samuli Ripatti Public Health Genomics Unit, National Institute for Health and Welfare, 00271 Helsinki, Finland. Samuli Ripatti Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK. Samuli Ripatti Department of Epidemiology and Biostatistics, MRC-HPA Center for Environment and Health, Imperial College London, London W2 1PG, UK. Marjo-Riitta Jarvelin Department of Psychiatry, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands. Brenda Penninx Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20852, USA. Stephen J. Chanock & Sonja I. Berndt Karolinska Institutet, 171 77 Stockholm, Sweden. Anders Hamsten Atherosclerosis Research Unit, Department of Medicine, Solna, 171 76 Stockholm, Sweden. Anders Hamsten Epidemiology, Biostatistics & HTA, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Lambertus A. Kiemeney & Sita H. Vermeulen National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA. David Schlessinger Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany. Sabine Schipf Department of Medicine, University of Leipzig, 04103 Leipzig, Germany. Michael Stumvoll & Anke Tönjes IFB Adiposity Diseases, University of Leipzig, 04103 Leipzig, Germany. Michael Stumvoll & Anke Tönjes Department of Epidemiology and Carolina Center for Genome Sciences, The University of North Carolina, Chapel Hill, North Carolina 27514, USA. Kari E. North Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Old Road Headington, Oxford OX3 7LJ, UK. Mark I. McCarthy Department of Psychiatry, Washington University St Louis, Missouri 63110, USA. Andrew C. Heath & Pamela A. F. Madden Department of Biostatistics, University of Washington, Seattle, Washington 98115, USA. Barbara McKnight Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, UK. William G. Hill Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland. Unnur Thorsteinsdottir & Kari Stefansson Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, University of Exeter, Exeter EX1 2LU, UK. Timothy M. Frayling Department of Food and Agricultural Systems, University of Melbourne, Victoria 3010, Australia. Michael E. Goddard Biosciences Research Division, Department of Primary Industries, Bundoora, Victoria 3083, Australia. Michael E. Goddard Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia. Peter M. Visscher (literal)
Titolo
  • FTO genotype is associated with phenotypic variability of body mass index. (literal)
Abstract
  • There is evidence across several species for genetic control of phenotypic variation of complex traits , such that the variance among phenotypes is genotype dependent. Understanding genetic control of variability is important in evolutionary biology, agricultural selection programmes and human medicine, yet for complex traits, no individual genetic variants associated with variance, as opposed to the mean, have been identified. Here we perform a meta-analysis of genome-wide association studies of phenotypic variation using ~170,000 samples on height and body mass index (BMI) in human populations. We report evidence that the single nucleotide polymorphism (SNP) rs7202116 at the FTO gene locus, which is known to be associated with obesity (as measured by mean BMI for each rs7202116 genotype) is also associated with phenotypic variability. We show that the results are not due to scale effects or other artefacts, and find no other experiment-wise significant evidence for effects on variability, either at loci other than FTO for BMI or at any locus for height. The difference in variance for BMI among individuals with opposite homozygous genotypes at the FTO locus is approximately 7%, corresponding to a difference of ~0.5 kilograms in the standard deviation of weight. Our results indicate that genetic variants can be discovered that are associated with variability, and that between-person variability in obesity can partly be explained by the genotype at the FTO locus. The results are consistent with reported FTO by environment interactions for BMI8, possibly mediated by DNA methylation9, 10. Our BMI results for other SNPs and our height results for all SNPs suggest that most genetic variants, including those that influence mean height or mean BMI, are not associated with phenotypic variance, or that their effects on variability are too small to detect even with samples sizes greater than 100,000. (literal)
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