Insulin sensitivity and beta-cell function in adults with lifetime, untreated isolated growth hormone deficiency (Articolo in rivista)

Type
Label
  • Insulin sensitivity and beta-cell function in adults with lifetime, untreated isolated growth hormone deficiency (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1210/jc.2011-2590 (literal)
Alternative label
  • Oliveira, C.R.;Salvatori, R.;Barreto-Filho, J.A.;Rocha, I.E.;Mari, A.;Pereira, R.M.;Campos, V.C.;Menezes, M.;Gomes, E.;Meneguz-Moreno, R.A.;Araujo, V.P.;Leite, N.T.;Nascimento-Junior, A.C.;Farias, M.I.;Viscente, T.A.;Araujo, R.D.;Melo, E.V.;Aguiar-Oliveira, M.H. (2012)
    Insulin sensitivity and beta-cell function in adults with lifetime, untreated isolated growth hormone deficiency
    in The Journal of clinical endocrinology and metabolism
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Oliveira, C.R.;Salvatori, R.;Barreto-Filho, J.A.;Rocha, I.E.;Mari, A.;Pereira, R.M.;Campos, V.C.;Menezes, M.;Gomes, E.;Meneguz-Moreno, R.A.;Araujo, V.P.;Leite, N.T.;Nascimento-Junior, A.C.;Farias, M.I.;Viscente, T.A.;Araujo, R.D.;Melo, E.V.;Aguiar-Oliveira, M.H. (literal)
Pagina inizio
  • 1013 (literal)
Pagina fine
  • 1019 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.ncbi.nlm.nih.gov/pubmed/22170707 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 97 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 3 (literal)
Note
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Oliveira, Barreto-Filho, Rocha, Pereira, Campos, Menezes, Gomes, Meneguz-Moreno, Araujo, Leite, Nascimento-Junior, Farias, Viscente, Araujo, Melo, Aguiar-Oliveira: Federal University of Sergipe, Division of Endocrinology, 49060-100 Aracaju, SE, Brazil; Salvatori: Division of Endocrinology, Johns Hopkins University School of Medicine, 1830 East Monument Street, Baltimore, MD 21287, United States; Mari: National Research Council, 35127 Padova, Italy (literal)
Titolo
  • Insulin sensitivity and beta-cell function in adults with lifetime, untreated isolated growth hormone deficiency (literal)
Abstract
  • : GH reduces insulin sensitivity (IS), whereas IGF-I increases it. IGF-I seems to be critical for the development of the ?-cells, and impaired IS has been reported in GH deficiency (GHD). Objective: The aim of the study was to assess IS and ?-cell function in adult patients with untreated isolated GHD (IGHD) due to a homozygous mutation in the GHRH receptor gene. Design, Setting, and Patients: We conducted a cross-sectional study in 24 GH-naive adult IGHD subjects and 25 controls. Intervention:We performed an oral glucose tolerance test with glucose and insulin measurements at 0, 30, 60, 90, 120, and 180 min. Main Outcome Measures: IS was assessed by homeostasis model assessment index of insulin resistance (IR), quantitative IS check index, oral glucose IS in 2 h (OGIS2) and 3 h (OGIS3). ?-Cell function was assayed by homeostasis model assessment index-?, insulinogenic index, and area under the curve of insulin-glucose ratio. Results:During the oral glucose tolerance test, glucoselevelswere higherinIGHD subjects (P?0.0001), whereas insulin response presented a trend toward reduction (P ? 0.08). The number of individuals with impaired glucose tolerance was higher in the IGHD group (P ? 0.001), whereas the frequency of diabetes was similar in the two groups. Homeostasismodel assessment index of IR was lower (P?0.04), and quantitative IS check index and OGIS2 showed a nonsignificant trend toward elevation (P ? 0.066 and P ? 0.09, respectively) in IGHD. OGIS3 showed no difference between the groups. Homeostasis model assessment index-?, insulinogenic index, and ratio of the areas of the insulin and glucose curves were reduced in the IGDH group (P ? 0.015, P ? 0.0001, and P ? 0.02, respectively). Conclusions: Adult subjects with lifetime congenital untreated IGHD present reduced ?-cell function, no evidence of IR, and higher frequency of impaired glucose tolerance. ( (literal)
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