Kwashiorkor and marasmus are both associated with impaired glucose clearance related to pancreatic ?-cell dysfunction (Articolo in rivista)

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  • Kwashiorkor and marasmus are both associated with impaired glucose clearance related to pancreatic ?-cell dysfunction (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.metabol.2012.01.019 (literal)
Alternative label
  • Spoelstra, M.N.;Mari, A.;Mendel, M.;Senga, E.;van Rheenen, P.;van Dijk, T.H.;Reijngoud, D.J.;Zegers, R.G.;Heikens, G.T.;Bandsma, R.H. (2012)
    Kwashiorkor and marasmus are both associated with impaired glucose clearance related to pancreatic ?-cell dysfunction
    in Metabolism, clinical and experimental (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Spoelstra, M.N.;Mari, A.;Mendel, M.;Senga, E.;van Rheenen, P.;van Dijk, T.H.;Reijngoud, D.J.;Zegers, R.G.;Heikens, G.T.;Bandsma, R.H. (literal)
Pagina fine
  • 1224 (literal)
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  • http://www.sciencedirect.com/science/article/pii/S0026049512000479# (literal)
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  • 91 (literal)
Rivista
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  • 1230 (literal)
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  • 9 (literal)
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  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Spoelstra, Mendel, Van Dijk, Reijngoud: Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, Groningen, the Netherlands; Mari: National Research Center, Institute of Biomedical Engineering, Padova, Italy; Senga: Department of Biochemistry, College of Medicine, University of Malawi, Blantyre, Malawi; van Rheenen: Department of Pediatrics, University Medical Center Groningen, Groningen, the Netherlands; Zegers: National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, MI, USA; Heikens: Department of Paediatrics and Child Health, College of Medicine, University of Malawi, Blantyre ; Bandsma: Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, Groningen, the Netherlands / Department of Biochemistry, College of Medicine, University of Malawi, Blantyre, Malawi (literal)
Titolo
  • Kwashiorkor and marasmus are both associated with impaired glucose clearance related to pancreatic ?-cell dysfunction (literal)
Abstract
  • Severe malnutrition is a major health problem in developing countries and can present as kwashiorkor or marasmus. Kwashiorkor is associated with septicaemia, profound metabolic changes including hepatic steatosis, altered protein metabolism and increased oxidative stress. Limited data suggest that children with kwashiorkor have an impaired glucose tolerance and insulin secretion. Our objective was to determine glucose tolerance in children with kwashiorkor compared to marasmus and its relation to insulin secretion and sensitivity. Six children with kwashiorkor and 8 children with marasmus were studied. We were also able to include 3 healthy children for comparison. They received a primed (13mg/kg), constant infusion (0.15mg/kg/min) of [6,6-(2)H(2)]glucose for 4h with serial blood sampling. In addition, an oral glucose tolerance test (OGTT) was performed with labeled 10mg/g [U-(13)C]glucose. Glucose clearance was determined using mathematical modeling. Glucose clearance rates during the OGTT were -392 (range 309) mL/kg in children with kwashiorkor, -156 (426) mL/kg in marasmus and 279 (345) mL/kg in the control group. Glucose clearance rates correlated with plasma albumin concentrations (r=0.67, P=.001). Insulin responses were strongly impaired in both kwashiorkor and marasmus. There was no indication of peripheral or hepatic insulin resistance in the malnourished groups. We show that glucose clearance rates are affected in both children with marasmus as well as kwashiorkor, which correlate with plasma albumin concentrations. The disturbed glucose clearance in malnutrition is related to an impairment in insulin availability. (literal)
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