CTX (Crosslaps) Rather than Osteopontin Is Associated with Disturbed Glucose Metabolism in Gestational Diabetes (Articolo in rivista)

Type
Label
  • CTX (Crosslaps) Rather than Osteopontin Is Associated with Disturbed Glucose Metabolism in Gestational Diabetes (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1371/journal.pone.0040947 (literal)
Alternative label
  • Winhofer, Y.;Kiefer, F.W.;Handisurya, A.;Tura, A.;Klein, K.;Schneider, B.;Marculescu, R.;Wagner, O.F.;Pacini, G.;Luger, A.;Stulnig, T.M.;Kautzky-Willer, A. (2012)
    CTX (Crosslaps) Rather than Osteopontin Is Associated with Disturbed Glucose Metabolism in Gestational Diabetes
    in PloS one
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Winhofer, Y.;Kiefer, F.W.;Handisurya, A.;Tura, A.;Klein, K.;Schneider, B.;Marculescu, R.;Wagner, O.F.;Pacini, G.;Luger, A.;Stulnig, T.M.;Kautzky-Willer, A. (literal)
Pagina inizio
  • e40947 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.ncbi.nlm.nih.gov/pubmed/22844418 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Winhofer, Kiefer, Luger, Kautzky-Willer: Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria / Handisurya: Division of Nephrology, Department ofInternal Medicine III, Medical University of Vienna, Vienna, Austria / Tura, Pacini: Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy / Klein: Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria / Schneider: CeMSIIS, Section of Medical Statistics, Medical University of Vienna, Vienna,Austria / Marculescu, Wagner: Clinical Institute for Medical and Chemical Laboratory Diagnostics, General Hospital of Vienna, Vienna, Austria / Stulnig: /Christian Doppler-Laboratory for Cardio-Metabolic Immunotherapy, Medical University of Vienna, Vienna, Austria / Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria (literal)
Titolo
  • CTX (Crosslaps) Rather than Osteopontin Is Associated with Disturbed Glucose Metabolism in Gestational Diabetes (literal)
Abstract
  • Objective:Reciprocal interaction between bone and glucose metabolism might play a pivotal role in the development of type 2 diabetes. We recently demonstrated that osteocalcin is increased in women with gestational diabetes (GDM) compared to healthy pregnant women and related to enhanced insulin secretion. Here, we aimed to investigate the role of the bone resorption marker CTX and osteopontin (OPN), a key molecule in subclinical inflammation underlying insulin resistance, in gestational diabetes. Methods:Insulin sensitivity and secretion (derived from OGTT) as well as CTX and osteopontin were investigated in 26 GDM and 52 women with normal glucose tolerance during pregnancy [CON] between 24th and 28th gestational weeks; 24 women also underwent postpartum examination. Results:CTX was significantly higher in GDM compared to CON (0.4460.20 vs.0.2860.12 ng/ml, p,.0001) and positively correlated with osteocalcin (R = 0.64, p,.0001) and parameters of insulin secretion. Osteopontin plasma concentrations were decreased in GDM compared to CON (28.81622.12 vs.37.68619.63 ng/ml, p = 0.04), and did not show any relation to insulin secretion or sensitivity, but were significantly correlated with CRP (R = 0.3, p,0.007) and liver enzymes. Twelve weeks after delivery CTX and OPN were increased compared to pregnancy (both p,.0001) and did not differ between GDM and CON. Conclusion:Our findings support the idea of a tight regulation between bone and glucose metabolism, and suggest, that less curbed CTX during pregnancy might be involved in osteocalcin-mediated amelioration of insulin secretion in GDM. On the other hand, osteopontin was unrelated to insulin resistance in GDM, but associated with inflammatory markers and liver enzymes in all women. (literal)
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