Recovery of hematopoietic activity in bone marrow from human immunodeficiency virus type 1-infected patients during highly active antiretroviral therapy. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Recovery of hematopoietic activity in bone marrow from human immunodeficiency virus type 1-infected patients during highly active antiretroviral therapy. (Articolo in rivista) (literal)

Anno

• 2000-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1089/088922200750005994 (literal)

Alternative label

• A. Isgrò, I. Mezzaroma, A. Aiuti, L. De Vita, F. Franchi, F. Pandolfi, C. Alario, F. Ficara, E. Riva, G. Antonelli, and F. Aiuti. (2000)
  Recovery of hematopoietic activity in bone marrow from human immunodeficiency virus type 1-infected patients during highly active antiretroviral therapy.
  in AIDS research and human retroviruses
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• A. Isgrò, I. Mezzaroma, A. Aiuti, L. De Vita, F. Franchi, F. Pandolfi, C. Alario, F. Ficara, E. Riva, G. Antonelli, and F. Aiuti. (literal)

Pagina inizio

• 1471 (literal)

Pagina fine

• 1479 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 16 (literal)

Rivista

• AIDS research and human retroviruses (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 15 (literal)

Note

• Google Scholar (literal)
• PubMe (literal)
• Scopus (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• A. Isgrò Division of Allergy and Clinical Immunology, University of Rome La Sapienza, 00185 Rome, Italy I. Mezzaroma Division of Allergy and Clinical Immunology, University of Rome La Sapienza, 00185 Rome, Italy A. Aiuti Telethon Institute for Gene Therapy (TIGET), Scientific Institute H.S. Raffaele, 20132 Milan, Italy L. De Vita Division of Allergy and Clinical Immunology, University of Rome La Sapienza, 00185 Rome, Italy F. Franchi Department of Clinical Medicine, University of Rome La Sapienza, 00185 Rome, Italy F. Pandolfi Division of Hematology, San Camillo Hospital, 00149 Rome, Italy C. Alario Division of Allergy and Clinical Immunology, University of Rome La Sapienza, 00185 Rome, Italy F. Ficara Telethon Institute for Gene Therapy (TIGET), Scientific Institute H.S. Raffaele, 20132 Milan, Italy E. Riva Institute of Virology, University of Rome La Sapienza, 00185 Rome, Italy G. Antonelli Institute of Virology, University of Rome La Sapienza, 00185 Rome, Italy F. Aiuti Division of Allergy and Clinical Immunology, University of Rome La Sapienza, 00185 Rome, Italy (literal)

Titolo

• Recovery of hematopoietic activity in bone marrow from human immunodeficiency virus type 1-infected patients during highly active antiretroviral therapy. (literal)

Abstract

• The mechanisms responsible for the hematopoietic failure in human immunodeficiency virus type 1 (HIV-1)-infected patients are still unknown. Several findings indicate that the in vitro proliferative potential of precursor cells from AIDS patients is reduced. The changes seen in bone marrow (BM) morphology and the defective BM functions associated with cytopenias have both been proposed as potential explanations. In patients treated with highly active antiretroviral therapy (HAART) an immune reconstitution associated with increased whole blood cell counts has been described. We have investigated the effects of HAART on the number of colony-forming cells (CFCs) and long-term culture-initiating cells (LTC-ICs), using long-term BM cell cultures (LTBMC) in a group of subjects with HIV-1 infection enrolled in an open study to evaluate the mechanisms of immune reconstitution during HAART. In each patient, the increase in colony growth was homogeneous, regardless of the type of hematopoietic progenitor cells assayed; in four subjects an increase in the most primitive progenitor cells (LTC-ICs) was observed. These findings were associated with the in vivo data showing increased numbers of BM mononuclear cells (BMMCs) after HAART and with a rise in peripheral CD4+ T cell counts and decreased levels of plasma HIV-1 RNA. A decreased number of hematopoietic progenitor cells and/or a defective modulation of progenitor cell growth might be the cause of the hematological abnormalities in AIDS patients. Controlling HIV-1 replication by HAART could determine a restoration of stem cell activity, probably because of the suppression of factors that inhibit normal hematopoiesis. (literal)

Prodotto di

• Istituto di Ricerca Genetica e Biomedica (IRGB) (Istituto)

Autore CNR

• FRANCESCA FICARA (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Recovery of hematopoietic activity in bone marrow from human immunodeficiency virus type 1-infected patients during highly active antiretroviral therapy." (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di Ricerca Genetica e Biomedica (IRGB) (Istituto)

Autore CNR di

• FRANCESCA FICARA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• AIDS research and human retroviruses (Rivista)

Insieme di parole chiave di

• Parole chiave di "Recovery of hematopoietic activity in bone marrow from human immunodeficiency virus type 1-infected patients during highly active antiretroviral therapy." (Insieme di parole chiave)