http://www.cnr.it/ontology/cnr/individuo/prodotto/ID19360
Microarray analysis identifies up-regulation of CD36 in human PBMC treated with endocannabinoids. (Articolo in rivista)
- Type
- Label
- Microarray analysis identifies up-regulation of CD36 in human PBMC treated with endocannabinoids. (Articolo in rivista) (literal)
- Anno
- 2006-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.imlet.2007.02.004 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Malfitano A;Toruner G; Laezza C; Husain S; Gazzero P;Bifulco M; Vitale E (literal)
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- Pagina fine
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- http://www.ncbi.nlm.nih.gov/pubmed/17360047 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
- European J of Human Genet (Supplement 1). 2006 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
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- Dipartimento di Scienze Farmaceutiche, Universita' di Salerno, Fisciano (Sa), Italy; Department of Microbiology and Molecular Genetics, UMDNJ-New Jersey Medical School, Newark, NJ, USA ; Istituto di Endocrinologia e Oncologia Sperimentale del CNR e Dipartimento di Biologia e Patologia Cellulare e Molecolare,
Università \"Federico II\" di Napoli, Italy; Istituto di Biochimica delle Proteine ed Enzimologia, CNR, Pozzuoli (literal)
- Titolo
- Microarray analysis identifies up-regulation of CD36 in human PBMC treated with endocannabinoids. (literal)
- Abstract
- In this study we analysed the regulation of gene expression by arvanil and anandamide in human peripheral blood mononuclear cells (PBMCs) to clarify their immunosuppressive properties. PBMCs were activated, leading to CD36 down regulation, that was normalized by arvanil and anandamide. We used microarray technology to identify a regulatory pattern associated with cell proliferation in the presence of both substances. CD3-CD28 stimulated PBMCs showed a pattern of up-regulated and down-regulated genes after treatment with these substances. We selected and analysed several genes chosen by their function in the regulation of cell proliferation. We showed a transcriptional control of the CD36 gene by arvanil and anandamide associated with an increased protein expression, thus suggesting a possible role of CD36 in anandamide and arvanil anti-inflammatory pattern. (c) 2007 Elsevier B.V. All rights reserved. (literal)
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