Mechanisms underlying toxicity induced by CdTe Quantum dots determined in an invertebrate model organism. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Mechanisms underlying toxicity induced by CdTe Quantum dots determined in an invertebrate model organism. (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.biomaterials.2011.11.041 (literal)

Alternative label

• Ambrosone A. a), Mattera L. a), Marchesano V. a), Quarta A. b), Susha A. c), Tino A. a), Rogach A.L. c), Tortiglione C. a) (2012)
  Mechanisms underlying toxicity induced by CdTe Quantum dots determined in an invertebrate model organism.
  in Biomaterials
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ambrosone A. a), Mattera L. a), Marchesano V. a), Quarta A. b), Susha A. c), Tino A. a), Rogach A.L. c), Tortiglione C. a) (literal)

Pagina inizio

• 1991 (literal)

Pagina fine

• 2000 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 33 (literal)

Rivista

• Biomaterials (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• doi:10.1016/j.biomaterials. 2011.11.041 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 10 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a) CNR-Istituto di Cibernetica \"E. Caianiello\", Via Campi Flegrei 34, 80078 Pozzuoli, Italy b) CNR-Istituto di Nanoscienze, NNL, Via Arnesano km 5, 73100 Lecce, Italy c) Department of Physics and Materials Science & Centre for Functional Photonics, City University of Hong Kong, SAR, Hong Kong (literal)

Titolo

• Mechanisms underlying toxicity induced by CdTe Quantum dots determined in an invertebrate model organism. (literal)

Abstract

• A systematic and thorough quantitative analysis of the in vivo effects of inorganic nanoparticles is extremely important for the design of functional nanomaterials for diagnostic and therapeutic applications, better understanding of their non-specificity toward tissues and cell types, and for assessments of their toxicity. This study was undertaken to examine the impact of CdTe quantum dots (QDs) on an invertebrate freshwater model organism, Hydra vulgaris, for assessment of long term toxicity effects. The continuous exposure of living polyps to sub-lethal doses of QDs caused time and dose dependent morphological damages more severe than Cd2þ ions at the same concentrations, impaired both reproductive and regenerative capability, activated biochemical and molecular responses. Of remarkable interest, low QD doses, apparently not effective, caused early changes in the expression of general stress responsive and apoptotic genes. The occurrence of subtle genetic variations, in the absence of morphological damages, indicates the importance of genotoxicity studies for nanoparticle risk assessment. The versatility in morphological, cellular, biochemical and molecular responses renders Hydra a perfect model system for high-throughput screening of toxicological and ecotoxicological impact of nanomaterials on human and environmental health. (literal)

Prodotto di

• Nanotecnologie per terapia genica, bioimaging e delivery di farmaci (MD.P01.025.005) (Modulo)
• Sistema Nervoso, Biomolecole e Nanobioscienze (MD.P01.025.007) (Modulo)
• Nanocompositi (MD.P06.015.002) (Modulo)
• Istituto di cibernetica \"Edoardo Caianiello\" (ISASI) (Istituto)

Autore CNR

• ANGELA TINO (Persona)
• CLAUDIA TORTIGLIONE (Unità di personale interno)
• ALESSANDRA QUARTA (Unità di personale interno)
• ALFREDO AMBROSONE (Persona)

Incoming links:

Autore CNR di

• CLAUDIA TORTIGLIONE (Unità di personale interno)
• ANGELA TINO (Persona)
• ALFREDO AMBROSONE (Persona)
• ALESSANDRA QUARTA (Unità di personale interno)

Prodotto

• Istituto di cibernetica \"Edoardo Caianiello\" (ISASI) (Istituto)
• Nanocompositi (MD.P06.015.002) (Modulo)
• Sistema Nervoso, Biomolecole e Nanobioscienze (MD.P01.025.007) (Modulo)
• Nanotecnologie per terapia genica, bioimaging e delivery di farmaci (MD.P01.025.005) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biomaterials (Rivista)