A spatial physiological model for p53 intracellular dynamics (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• A spatial physiological model for p53 intracellular dynamics (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.jtbi.2012.08.035 (literal)

Alternative label

• Luna Dimitrio, Jean Clairambault, Roberto Natalini (2013)
  A spatial physiological model for p53 intracellular dynamics
  in Journal of theoretical biology; Elsevier, Oxford (Regno Unito)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Luna Dimitrio, Jean Clairambault, Roberto Natalini (literal)

Pagina inizio

• 9 (literal)

Pagina fine

• 24 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.sciencedirect.com/science/article/pii/S0022519312004572 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 316 (literal)

Rivista

• Journal of theoretical biology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 15 (literal)

Note

• PubMe (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• INRIA Paris-Rocquencourt & UPMC, 4 Place Jussieu, F-75005 Paris, France INRIA Paris-Rocquencourt & UPMC, 4 Place Jussieu, F-75005 Paris, France IAC-CNR & Via dei Taurini 19, I-00185 Rome, Italy (literal)

Titolo

• A spatial physiological model for p53 intracellular dynamics (literal)

Abstract

• In this paper we design and analyse a physiologically based model representing the accumulation of protein p53 in the nucleus after triggering of ATM by DNA damage. The p53 protein is known to have a central role in the response of the cell to cytotoxic or radiotoxic insults resulting in DNA damage. A reasonable requirement for a model describing intracellular signalling pathways is taking into account the basic feature of eukaryotic cells: the distinction between nucleus and cytoplasm. Our aim is to show, on a simple reaction network describing p53 dynamics, how this basic distinction provides a framework which is able to yield expected oscillatory dynamics without introducing either positive feedbacks or delays in the reactions. Furthermore we prove that oscillations appear only if some spatial constraints are respected, e.g. if the diffusion coefficients correspond to known biological values. Finally we analyse how the spatial features of a cell influence the dynamic response of the p53 network to DNA damage, pointing out that the protein oscillatory dynamics is indeed a response that is robust towards changes with respect to cellular environments. Even if we change the cell shape or its volume or better its ribosomal distribution, we observe that DNA damage yields sustained oscillations of p53. (literal)

Editore

• Elsevier (Editore)

Prodotto di

• Istituto per le applicazioni del calcolo \"Mauro Picone\" (IAC) (Istituto)
• Trasmissione di segnali intracellulari (INT.P02.004.002) (Modulo)

Autore CNR

• ROBERTO NATALINI (Persona)

Insieme di parole chiave

• Parole chiave di "A spatial physiological model for p53 intracellular dynamics" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto per le applicazioni del calcolo \"Mauro Picone\" (IAC) (Istituto)
• Trasmissione di segnali intracellulari (INT.P02.004.002) (Modulo)

Autore CNR di

• ROBERTO NATALINI (Persona)

Editore di

• Elsevier (Editore)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of theoretical biology (Rivista)

Insieme di parole chiave di

• Parole chiave di "A spatial physiological model for p53 intracellular dynamics" (Insieme di parole chiave)