http://www.cnr.it/ontology/cnr/individuo/prodotto/ID19201

Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance (Articolo in rivista) (literal)

Anno

2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1038/ijo.2009.242 (literal)

Alternative label

Moreno-Navarrete, JM 1,2; Manco, M 3; Ibanez, J 4; Garcia-Fuentes, E 5; Ortega, F 1,2; Gorostiaga, E 4; Vendrell, J 6; Izquierdo, M 4; Martinez, C 4; Nolfe, G 7; Ricart, W 1,2; Mingrone, G 8; Tinahones, F 5; Fernandez-Real, JM 1,2 (2010)
Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance
in International journal of obesity
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Moreno-Navarrete, JM 1,2; Manco, M 3; Ibanez, J 4; Garcia-Fuentes, E 5; Ortega, F 1,2; Gorostiaga, E 4; Vendrell, J 6; Izquierdo, M 4; Martinez, C 4; Nolfe, G 7; Ricart, W 1,2; Mingrone, G 8; Tinahones, F 5; Fernandez-Real, JM 1,2 (literal)

Pagina inizio

240 (literal)

Pagina fine

249 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

34 (literal)

Rivista

International journal of obesity (Rivista)

Note

ISI Web of Science (WOS) (literal)
PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigacio´ Biome´dica de Girona (IdIBGi) and University 1. IdIBGi, Dept Diabet Endocrinol & Nutr, Girona, Catalonia, Spain 2. Univ Hosp Dr Josep Trueta, CIBER Fisiopatol Obesidad & Nutr CB06 03 010, Girona, Catalonia, Spain 3. Bambino Gesu Pediat Hosp, Dept Sci Directorate, Rome, Italy 4. Govt Navarra, Res & Sports Med Ctr, Dept Studies, Pamplona, Spain 5. Hosp Virgen Victoria Malaga, CIBEROBN Fisiopatol Obesidad & Nutr CB06 03 018, Inst Salud Carlos III, Dept Endocrinol & Nutr, Malaga, Spain 6. Univ Hosp Tarragona, Dept Endocrinol, Tarragona, Spain 7. Ist Caianiello, Dept CNR, Pozzuoli, Italy 8. Catholic Univ, Dept Internal Med, Rome, Italy (literal)

Titolo

Metabolic endotoxemia and saturated fat contribute to circulating NGAL concentrations in subjects with insulin resistance (literal)

Abstract

Objective: Lipocalin-2 (neutrophil gelatinase-associated lipocalin, NGAL) is an innate immune system protein that has been linked to insulin resistance and obesity, but the mechanisms behind these associations are poorly known. We hypothesized that endotoxin (lipopolysaccharide, LPS) and fat intake were in the background of these associations. Design: We studied four cohorts: (1) a cross-sectional study in 194 subjects; (2) the changes in NGAL concentration induced by diet and weight loss in 36 obese women (with circadian rhythm in 8 of them); (3) the effects of acute fat intake on circulating NGAL concentration in 42 morbidly obese subjects; and (4) LPS-induced NGAL secretion ex vivo (whole blood and adipose tissue explants). Results: Serum NGAL concentration was significantly associated with fasting triglycerides and LPS-binding protein in patients with type 2 diabetes. In obese subjects, the intake of saturated fatty acids was the factor that best explained the variance of NGAL changes after weight loss (contributing independently to 14% of NGAL variance). In fact, weight loss significantly changed the circadian rhythm of NGAL. The acute increase in circulating NGAL after fat overload was significantly associated with fasting insulin (r¼0.52, Po0.001), homeostasis model assessment of insulin resistance (HOMA-IR) (r¼0.36, P¼0.02) and post-load triglyceride concentrations (r¼0.38, P¼0.018). LPS-induced NGAL secretion from adipose tissue explants did not change significantly, but LPS led to a significant increase in NGAL concentration in the whole blood obtained from patients with type 2 diabetes. Conclusion: Metabolic endotoxemia and saturated fat might contribute to circulating NGAL concentration in patients with insulin resistance. (literal)

Prodotto di