http://www.cnr.it/ontology/cnr/individuo/prodotto/ID19173

Circadian rhytms of GIP and GLP1 in glucose-tolerant and type 2 diabetic patients after biliopancreatic diversion (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Circadian rhytms of GIP and GLP1 in glucose-tolerant and type 2 diabetic patients after biliopancreatic diversion (Articolo in rivista) (literal)

Anno

2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1007/s00125-009-1288-9 (literal)

Alternative label

Mingrone, G 1; Nolfe, G (Nolfe, G.)2; Gissey, G. Castagneto Gissey 3; Iaconelli, A 1; Leccesi, L 1; Guidone, C 1; Nanni, G 4; Holst, JJ 5 (2009)
Circadian rhytms of GIP and GLP1 in glucose-tolerant and type 2 diabetic patients after biliopancreatic diversion
in Diabetologia (Berl.)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Mingrone, G 1; Nolfe, G (Nolfe, G.)2; Gissey, G. Castagneto Gissey 3; Iaconelli, A 1; Leccesi, L 1; Guidone, C 1; Nanni, G 4; Holst, JJ 5 (literal)

Pagina inizio

873 (literal)

Pagina fine

881 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

52 (literal)

Rivista

Diabetologia (Rivista)

Note

PubMe (literal)
ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1. Univ Cattolica Sacro Cuore, Dept Internal Med, I-00168 Rome, Italy 2. Inst Cybernet E Caianiello, CNR, Pozzuoli, Italy 3. Univ Kent, Dept Econ, Canterbury, Kent, England 4. Univ Cattolica Sacro Cuore, Dept Surg, I-00168 Rome, Italy 5. Univ Copenhagen, Panum Inst, Dept Biomed Sci, DK-2200 Copenhagen, Denmark (literal)

Titolo

Circadian rhytms of GIP and GLP1 in glucose-tolerant and type 2 diabetic patients after biliopancreatic diversion (literal)

Abstract

Aims/hypothesis We tested the hypothesis that the reversibility of insulin resistance and diabetes observed after biliopancreatic diversion (BPD) is related to changes in circadian rhythms of gastrointestinal hormones. Methods Ten morbidly obese participants, five with normal glucose tolerance (NGT) and five with type 2 diabetes, were studied before and within 2 weeks after BPD. Withinday variations in glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP1) levels were assessed using a single cosinor model. Insulin sensitivity was assessed by euglycaemic-hyperinsulinaemic clamp. Results Basal GLP1 relative amplitude (amplitude/ mesor×100) was 25.82-4.06% in NGT; it increased to 41.38-4.32% after BPD but was unchanged in diabetic patients. GLP1 and GIP mesor were shifted in time after surgery in diabetic patients but not in NGT participants. After BPD, the GLP1 AUC significantly increased from 775±94 to 846±161 pmol l-1 min in NGT, whereas GIP AUC decreased significantly from 1,373±565 to 513±186 pmol l-1 min in diabetic patients. Two-way ANOVA showed a strong influence of BPD on both GIP (p=0.010) and GLP1 AUCs (p=0.033), which was potentiated by the presence of diabetes, particularly for GIP (BPD×diabetes, p=0.003). Insulin sensitivity was markedly improved (p<0.01) in NGT (from 9.14± 3.63 to 36.04±8.55 ?mol [kg fat-free mass]-1 min-1) and diabetic patients (from 9.49±3.56 to 38.57±4.62 ?mol [kg fat-free mass]-1 min-1). Conclusions/interpretation An incretin circadian rhythm was shown for the first time in morbid obesity. The effect of BPD on the 24 h pattern of incretin differed between NGT and diabetic patients. GLP1 secretion impairment was reversed in NGT and could not be overcome by surgery in diabetes. On the other hand, GIP secretion was blunted after the operation only in diabetic patients, suggesting a role in insulin resistance and diabetes. (literal)

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