Melanoma pathophysiology and drug targets (Contributo in volume (capitolo o saggio))

Type
Label
  • Melanoma pathophysiology and drug targets (Contributo in volume (capitolo o saggio)) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • Giuseppe Palmieri, Carla Rozzo, Giusy Gentilcore & Paolo Antonio Ascierto (2012)
    Melanoma pathophysiology and drug targets
    Future Medicine Ltd., London (Regno Unito) in Emerging therapeutics for melanoma, 2012
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Giuseppe Palmieri, Carla Rozzo, Giusy Gentilcore & Paolo Antonio Ascierto (literal)
Pagina inizio
  • 7 (literal)
Pagina fine
  • 17 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#titoloVolume
  • Emerging therapeutics for melanoma (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 11 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CNR-ICB, Sassari Istituto Tumori, Napoli (literal)
Titolo
  • Melanoma pathophysiology and drug targets (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#isbn
  • 978-1-78084-116-8 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#curatoriVolume
  • Francesco M Marincola, Paolo Ascierto & John M Kirkwood (literal)
Abstract
  • Characterization of the key molecular mechanisms involved in the development and progression of melanoma may contribute to improve classification, treatment and management of patients with such a disease. Indeed, increasing evidence suggests that melanoma develops as a result of accumulated alterations in genetic and molecular pathways in melanocytic cells, generating different subsets of melanoma patients with diverse biology, clinical patterns of behavior and response to therapy. Knowledge of the main features underlying the pathogenesis of melanoma is now mandatory for clinicians. The success of the V600EBRAF inhibitors (such as vemurafenib) in the treatment of the advanced disease underlines the importance of the molecular signature. (literal)
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