Quartz Crystal Microbalance with Dissipation (QCM-D) as tool to exploit *antigen-antibody interactions in pancreatic ductal adenocarcinoma detection (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Quartz Crystal Microbalance with Dissipation (QCM-D) as tool to exploit *antigen-antibody interactions in pancreatic ductal adenocarcinoma detection (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.bios.2012.10.012 (literal)

Alternative label

• M. Bianco, A. Aloisi, V. Arima, M. Capello, S. Ferri-Borgogno, F. Novelli, S. Leporatti and R. Rinaldi (2013)
  Quartz Crystal Microbalance with Dissipation (QCM-D) as tool to exploit *antigen-antibody interactions in pancreatic ductal adenocarcinoma detection
  in Biosensors & bioelectronics
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• M. Bianco, A. Aloisi, V. Arima, M. Capello, S. Ferri-Borgogno, F. Novelli, S. Leporatti and R. Rinaldi (literal)

Pagina inizio

• 646 (literal)

Pagina fine

• 652 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 42 (literal)

Rivista

• Biosensors & bioelectronics (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• NNL--Institute of Nanoscience (NANO), CNR,Via per Arnesano 16, Lecce I-73100, Italy Center for Experimental Researchand Medical Studies (CERMS) University of Turin San Giovanni Battista University Hospital via Cherasco 15, Turin 10126, Italy Department of Medicine and Experimental Oncology, University of Turin, Via Michelangelo 27, Torino 10125, Italy Università del Salento, Dipartimento di Matematica e Fisica ''E.DeGiorgi'', ex Collegio Fiorini Campus extraurbano,via per Arnesano, Lecce 73100, Italy (literal)

Titolo

• Quartz Crystal Microbalance with Dissipation (QCM-D) as tool to exploit *antigen-antibody interactions in pancreatic ductal adenocarcinoma detection (literal)

Abstract

• Novel synthetic peptides represent smart molecules for antigen antibody interactions in several bioanalytics applications, from purification to serum screening. Their immobilization onto a solid phase is considered a key point for sensitivity increasing. In this view, we exploited Quartz Crystal Microbalance with simultaneous frequency and dissipation monitoring (QCM-D) with a double aim, specifically, as investigative tool for spacers monolayer assembling and its functional evaluation, as well as high sensitive method for specific immunosorbent assays. The method was applied to pancreatic ductal adenocarcinoma (PDAC) detection by studying the interactions between synthetic phosphorylated and un-phosphorylated alpha-enolase peptides with sera of healthy and PDAC patients. The synthetic peptides were immobilized on the gold surface of the QCM-D sensor via a self-assembled alkanethiol monolayer. The presented experimental results can be applied to the development of surfaces less sensitive to non-specific interactions with the final target to suggest specific protocols for detecting PDAC markers with un-labeled biosensors. (literal)

Prodotto di

• Nanobiotecnologie & Nanobioelettronica (MD.P06.008.004) (Modulo)

Autore CNR

• VALENTINA ARIMA (Unità di personale interno)
• Monica Bianco (Persona)
• ROSARIA RINALDI (Unità di personale esterno)
• STEFANO LEPORATTI (Persona)
• ALESSANDRA ALOISI (Unità di personale esterno)

Incoming links:

Autore CNR di

• ROSARIA RINALDI (Unità di personale esterno)
• Monica Bianco (Persona)
• ALESSANDRA ALOISI (Unità di personale esterno)
• VALENTINA ARIMA (Unità di personale interno)
• STEFANO LEPORATTI (Persona)

Prodotto

• Nanobiotecnologie & Nanobioelettronica (MD.P06.008.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biosensors & bioelectronics (Rivista)