http://www.cnr.it/ontology/cnr/individuo/prodotto/ID19050

Synthesis and biological evaluation of phorbol-resiniferatoxin (RTX) hybrids (Articolo in rivista)

Type

Label

Synthesis and biological evaluation of phorbol-resiniferatoxin (RTX) hybrids (Articolo in rivista) (literal)

Anno

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

Alternative label

Appendino G., Bertolino A., Minassi A., Annunziata R., Szallasi A., De Petrocellis L., Di Marzo V. (2004)
Synthesis and biological evaluation of phorbol-resiniferatoxin (RTX) hybrids
in European journal of organic chemistry (Print); WILEY-V C H VERLAG GMBH,, D-69451 WEINHEIM, (Germania)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Appendino G., Bertolino A., Minassi A., Annunziata R., Szallasi A., De Petrocellis L., Di Marzo V. (literal)

Pagina inizio

Pagina fine

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

Rivista

Note

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1. Dipartimento Sci Chim Alimentari Farmaceut & Farm, I-28100 Novara, Italy 2. Dipartimento Sci & Tecnol Farmaco, I-10125 Turin, Italy 3. Dipartimento Chim Organ & Ind, I-20133 Milan, Italy 4. Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA 5. CNR, Ist Cibernetica, Endocannabinoid Res Grp, I-80078 Pozzuoli, Italy 6. CNR, Ist Chim Biomolecolare, Endocannabinoid Res Grp, I-80078 Pozzuoli, Italy (literal)

Titolo

Synthesis and biological evaluation of phorbol-resiniferatoxin (RTX) hybrids (literal)

Abstract

Phorboid 20-homovanillates modified on ring C to mimic the constitution and conformation of the ultrapotent vanilloid resiniferatoxin (RTX) and on the AB ring system to suppress the tumour-promoting potential of the terpenoid core were prepared. Several unexpected reactions were discovered, and the structure-activity relationships for this class of vanilloid ligands were expanded. (literal)

Editore