IFITM3 restricts the morbidity and mortality associated with influenza (Articolo in rivista)

Type
Label
  • IFITM3 restricts the morbidity and mortality associated with influenza (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/nature10921 (literal)
Alternative label
  • Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB; GenISIS Investigators; MOSAIC Investigators, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P. et al. (2012)
    IFITM3 restricts the morbidity and mortality associated with influenza
    in Nature (Lond.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB; GenISIS Investigators; MOSAIC Investigators, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P. et al. (literal)
Pagina inizio
  • 519 (literal)
Pagina fine
  • 523 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 484 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 7595 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK Aaron R. Everitt, Simon Clare, Rachael S. Wash, Sarah E. Smith, David J. Adams, Leanne Kane, David Goulding, Verneri Anttila, Aarno Palotie, Yali Xue, Vincenza Colonna, Chris Tyler-Smith, Gordon Dougan & Paul Kellam Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Charlestown, Massachusetts 02129, USA Thomas Pertel, Sinu P. John, Christopher R. Chin, Eric M. Feeley, Jennifer S. Sims & Abraham L. Brass Divison of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK Helen M. Wise & Paul Digard Division of Genetics and Genomics, The Roslin Institute, University of Edinburgh, Roslin EH25 9RG, UK J. Kenneth Baillie & David A. Hume Department of Critical Care Medicine, University of Edinburgh, Edinburgh EH16 4TJ, UK J. Kenneth Baillie & Tim S. Walsh Institute of Genetics and Biophysics \"A. Buzzati-Traverso\", National Research Council (CNR), Naples, Italy Vincenza Colonna Centre for Respiratory Infection, National Heart and Lung Institute, St Mary's Campus, Imperial College London, W2 1PG, UK Jake Dunning & Peter J. Openshaw Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK Stephen B. Gordon Institute of Translational Medicine, University of Liverpool, Alder Hey Children's Hospital, Liverpool L12 2AP, UK Rosalind L. Smyth Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02117, USA Abraham L. Brass UCL/MRC Centre for Medical Molecular Virology, Department of Infection, University College London, Cleveland Street, London W1T 4JF, UK Paul Kellam Benaroya Research Institute, 1201 9th Avenue, Seattle, Washington 98101-2795, USA. D. Chaussabel West of Scotland Specialist Virology Centre, Gartnavel General Hospital, Glasgow and Clyde Health Board, 1053 Great Western Road, Glasgow G12 0YN, UK. W. E. Adamson & W. F. Carman Health Protection Agency, Microbiology Services Colindale, 61 Colindale Avenue, London NW9 5EQ, UK. C. Thompson & M. C. Zambon Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK. P. Aylin, D. Ashby, W. S. Barclay, S. J. Brett, W. O. Cookson, L. N. Drumright, J. Dunning, R. A. Elderfield, L. Garcia-Alvarez, B. G. Gazzard, M. J. Griffiths, M. S. Habibi, T. T. Hansel, J. A. Herberg, A. H. Holmes, T. Hussell, S. L. Johnston, O. M. Kon, M. Levin, M. F. Moffatt, S. Nadel, P. J. Openshaw & J. O. Warner Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK. S. J. Aston & S. B. Gordon National Institute for Medical Research (NIMR), The Ridgeway, London NW7 1AA, UK. A. Hay, J. McCauley & A. O'Garra Roche, 340 Kingsland Street, Nutley, New Jersey 07110-1199, USA. J. Banchereau University College London, Gower Street, London, WC1E 6BT, UK. A. Hayward & P. Kellam The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK. J. K. Baillie, D. A. Hume & P. Simmonds Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool, Alder Hey Children's Hospital, Liverpool L12 2AP, UK. P. S. McNamara, M. G. Semple & R. L. Smyth Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK. J. S. Nguyen-Van-Tam The Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK. L.-P. Ho & A. J. McMichael Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. P. Kellam Department of Critical Care Medicine, The Queen's Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, 47 Little France Drive, Edinburgh EH16 4TJ, UK K. Everingham, H. Dawson, D. Hope, P. Ramsay & T. S. Walsh Generation Scotland, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK. A. Campbell & S. Kerr Intensive Care National Audit & Research Centre, Tavistock House, Tavistock Square, London WC1H 9HR, UK. D. Harrison & K. Rowan Intensive Care Unit, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK. J. Addison, N. Donald, S. Galt, D. Noble, J. Taylor & N. Webster Intensive Care Unit, Ayr Hospital, Dallmellington Road, Ayr KA6 6DX, UK. I. Taylor Intensive Care Unit, Borders General Hospital, Melrose TD6 9BS, UK. J. Aldridge, R. Dornan & C. Richard Intensive Care Unit, Crosshouse Hospital, Kilmarnock KA2 0BE, UK. D. Gilmour, R. Simmons & R. White Intensive Care Unit, Dumfries and Galloway Royal Infirmary, Dumfries DG1 4AP, UK. C. Jardine & D. Williams Intensive Care Unit, Glasgow Royal Infirmary, Glasgow G4 0SF, UK. M. Booth & T. Quasim Intensive Care Unit, Hairmyres Hospital, Lanarkshire G75 8RG, UK. V. Watson Intensive Care Unit, Inverclyde Royal Hospital, Greenock PA16 0XN, UK. P. Henry & F. Munro Intensive Care Unit, Monklands Hospital, Airdrie ML6 0JS, UK. L. Bell & J. Ruddy Intensive Care Unit, Ninewells Hospital, Dundee DD1 9SY, UK. S. Cole & J. Southward Intensive Care Unit, Queen Margaret Hospital, Dunfermline KY12 0SU, UK. P. Allcoat, S. Gray & M. McDougall Intensive Care Unit, Raigmore Hospital, Inverness IV2 3UJ, UK. J. Matheson & J. Whiteside Intensive Care Unit, Royal Alexandra Hospital, Paisley PA2 9PN, UK. D. Alcorn, K. Rooney & R. Sundaram Intensive Care Unit, Southern General Hospital, Glasgow G51 4TF, UK. G. Imrie Intensive Care Unit, St John's Hospital, Livingston EH54 6PP, UK. J. Bruce, K. McGuigan & S. Moultrie Intensive Care Unit, Stirling Royal Infirmary, Stirling FK8 2AU, UK. C. Cairns, J. Grant & M. Hughes Intensive Care Unit, Stobhill Hospital, Glasgow G21 3UW, UK. C. Murdoch Intensive Care Unit, Victoria Hospital, Glasgow G42 9TY, UK. A. Davidson Intensive Care Unit, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK. G. Harris, R. Paterson & C. Wallis Intensive Care Unit, Western Infirmary, Glasgow G11 6NT, UK. S. Binning & M. Pollock Wellcome Trust Clinical Research Facility, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK. J. Antonelli, A. Duncan, J. Gibson, C. McCulloch & L. Murphy Division of Genetics and Genomics, The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK. C. Haley, G. Faulkner, T. Freeman, D. A. Hume & J. K. Baillie Consortia The GenISIS Investigators Critical Care Medicine, University of Edinburgh K. Everingham, H. Dawson, D. Hope, P. Ramsay & T. S. Walsh (Local Lead Investigator) Generation Scotland, University of Edinburgh Molecular Medicine Centre A. Campbell & S. Kerr Intensive Care National Audit & Research Centre, London D. Harrison & K. Rowan Intensive Care Unit, Aberdeen Royal Infirmary J. Addison, N. Donald, S. Galt, D. Noble, J. Taylor & N. Webster (Local Lead Investigator) Intensive Care Unit, Ayr Hospital I. Taylor (Local Lead Investigator) Intensive Care Unit, Borders General Hospital, Melrose J. Aldridge (Local Lead Investigator), R. Dornan & C. Richard Intensive Care Unit, Crosshouse Hospital, Kilmarnock D. Gilmour, R. Simmons (Local Lead Investigator) & R. White (Local Lead Investigator) Intensive Care Unit, Dumfries and Galloway Royal Infirmary C. Jardine & D. Williams (Local Lead Investigator) Intensive Care Unit, Glasgow Royal Infirmary M. Booth (Local Lead Investigator) & T. Quasim Intensive Care Unit, Hairmyres Hospital, Lanarkshire V. Watson Intensive Care Unit, Inverclyde Royal Hospital, Greenock P. Henry & F. Munro Intensive Care Unit, Monklands Hospital, Airdrie L. Bell & J. Ruddy (Local Lead Investigator) Intensive Care Unit, Ninewells Hospital, Dundee S. Cole (Local Lead Investigator) & J. Southward Intensive Care Unit, Queen Margaret Hospital, Dunfermline P. Allcoat, S. Gray & M. McDougall (Local Lead Investigator) Intensive Care Unit, Raigmore Hospital, Inverness J. Matheson & J. Whiteside (Local Lead Investigator) Intensive Care Unit, Royal Alexandra Hospital, Paisley D. Alcorn, K. Rooney (Local Lead Investigator) & R. Sundaram Intensive Care Unit, Southern General Hospital, Glasgow G. Imrie (Local Lead Investigator) Intensive Care Unit, St John's Hospital, Livingston J. Bruce, K. McGuigan & S. Moultrie (Local Lead Investigator) Intensive Care Unit, Stirling Royal Infirmary C. Cairns (Local Lead Investigator), J. Grant & M. Hughes Intensive Care Unit, Stobhill Hospital, Glasgow C. Murdoch (Local Lead Investigator) Intensive Care Unit, Victoria Hospital, Glasgow A. Davidson (Local Lead Investigator) Intensive Care Unit, Western General Hospital, Edinburgh G. Harris, R. Paterson & C. Wallis (Local Lead Investigator) Intensive Care Unit, Western Infirmary, Glasgow S. Binning (Local Lead Investigator) & M. Pollock Wellcome Trust Clinical Research Facility, Edinburgh J. Antonelli, A. Duncan, J. Gibson, C. McCulloch & L. Murphy Roslin Institute, University of Edinburgh C. Haley, G. Faulkner, T. Freeman, D. A. Hume & J. K. Baillie (Principal Investigator) The MOSAIC Investigators Benaroya Research Institute, USA D. Chaussabel Gartnavel General Hospital, Greater Glasgow, UK W. E. Adamson & W. F. Carman Health Protection Agency, UK C. Thompson & M. C. Zambon Imperial College London, UK P. Aylin, D. Ashby, W. S. Barclay, S. J. Brett, W. O. Cookson, L. N. Drumright, J. Dunning, R. A. Elderfield, L. Garcia-Alvarez, B. G. Gazzard, M. J. Griffiths, M. S. Habibi, T. T. Hansel, J. A. Herberg, A. H. Holmes, T. Hussell, S. L. Johnston, O. M. Kon, M. Levin, M. F. Moffatt, S. Nadel, P. J. Openshaw & J. O. Warner Liverpool School of Tropical Medicine, UK S. J. Aston & S. B. Gordon National Institute for Medical Research, UK A. Hay, J. McCauley & A. O'Garra Roche, Nutley, USA J. Banchereau University College London, UK A. Hayward & P. Kellam University of Edinburgh, UK J. K. Baillie, D. A. Hume & P. Simmonds University of Liverpool, UK P. S. McNamara, M. G. Semple & R. L. Smyth University of Nottingham, UK J. S. Nguyen-Van-Tam University of Oxford, UK L.-P. Ho & A. J. McMichael Wellcome Trust Sanger Institute, UK P. Kellam (literal)
Titolo
  • IFITM3 restricts the morbidity and mortality associated with influenza (literal)
Abstract
  • The 2009 H1N1 influenza pandemic showed the speed with which a novel respiratory virus can spread and the ability of a generally mild infection to induce severe morbidity and mortality in a subset of the population. Recent in vitro studies show that the interferon-inducible transmembrane (IFITM) protein family members potently restrict the replication of multiple pathogenic viruses. Both the magnitude and breadth of the IFITM proteins' in vitro effects suggest that they are critical for intrinsic resistance to such viruses, including influenza viruses. Using a knockout mouse model, we now test this hypothesis directly and find that IFITM3 is essential for defending the host against influenza A virus in vivo. Mice lacking Ifitm3 display fulminant viral pneumonia when challenged with a normally low-pathogenicity influenza virus, mirroring the destruction inflicted by the highly pathogenic 1918 'Spanish' influenza. Similar increased viral replication is seen in vitro, with protection rescued by the re-introduction of Ifitm3. To test the role of IFITM3 in human influenza virus infection, we assessed the IFITM3 alleles of individuals hospitalized with seasonal or pandemic influenza H1N1/09 viruses. We find that a statistically significant number of hospitalized subjects show enrichment for a minor IFITM3 allele (SNP rs12252-C) that alters a splice acceptor site, and functional assays show the minor CC genotype IFITM3 has reduced influenza virus restriction in vitro. Together these data reveal that the action of a single intrinsic immune effector, IFITM3, profoundly alters the course of influenza virus infection in mouse and humans. (literal)
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