Genome-wide meta-analysis of common variant differences between men and women. (Articolo in rivista)

Type
Label
  • Genome-wide meta-analysis of common variant differences between men and women. (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1093/hmg/dds304 (literal)
Alternative label
  • Boraska V, Jeroncic A, Colonna V, Southam L, Nyholt DR, William Rayner N, Perry JR, Toniolo D, Albrecht E, Ang W, Bandinelli S, Barbalic M, Barroso I, Beckmann JS, Biffar R, Boomsma D, Campbell H, Corre T, Erdmann J, Esko T, Fischer K, Franceschini N, Frayling TM, Girotto G, Gonzalez JR, Harris TB, Heath AC, Heid IM, Hoffmann W, Hofman A, Horikoshi M, Hua Zhao J, Jackson AU, Hottenga JJ, Jula A, Kähönen M, Khaw KT, Kiemeney LA, Klopp N, Kutalik Z, Lagou V, Launer LJ, Lehtimäki T, Lemire M, Lokki ML, Loley C, Luan J, Mangino M, Mateo Leach I, Medland SE, Mihailov E, Montgomery GW, Navis G, Newnham J, Nieminen MS, Palotie A, Panoutsopoulou K, Peters A, Pirastu N, Polasek O, Rehnström K, Ripatti S, Ritchie GR, Rivadeneira F, Robino A, Samani NJ, Shin SY, Sinisalo J, Smit JH, Soranzo N, Stolk L, Swinkels DW, Tanaka T, Teumer A, Tönjes A, Traglia M, Tuomilehto J, Valsesia A, van Gilst WH, van Meurs JB, Smith AV, Viikari J, Vink JM, Waeber G, Warrington NM, Widen E, Willemsen G, Wright AF, Zanke BW, Zgaga L; Wellcome Trust Case Control Consortium (WTCCC), Boehnke M, d'Adamo AP, de Geus E, Demerath EW, den Heijer M, Eriksson JG, Ferrucci L, Gieger C, Gudnason V, Hayward C, Hengstenberg C, Hudson TJ, Järvelin MR, Kogevinas M, Loos RJ, Martin NG, Metspalu A, Pennell CE, Penninx BW, Perola M, Raitakari O, Salomaa V, Schreiber S, Schunkert H, Spector TD, Stumvoll M, Uitterlinden AG, Ulivi S, van der Harst P, Vollenweider P, Völzke H, Wareham NJ, Wichmann HE, Wilson JF, Rudan I, Xue Y, Zeggini E. (2012)
    Genome-wide meta-analysis of common variant differences between men and women.
    in Human molecular genetics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Boraska V, Jeroncic A, Colonna V, Southam L, Nyholt DR, William Rayner N, Perry JR, Toniolo D, Albrecht E, Ang W, Bandinelli S, Barbalic M, Barroso I, Beckmann JS, Biffar R, Boomsma D, Campbell H, Corre T, Erdmann J, Esko T, Fischer K, Franceschini N, Frayling TM, Girotto G, Gonzalez JR, Harris TB, Heath AC, Heid IM, Hoffmann W, Hofman A, Horikoshi M, Hua Zhao J, Jackson AU, Hottenga JJ, Jula A, Kähönen M, Khaw KT, Kiemeney LA, Klopp N, Kutalik Z, Lagou V, Launer LJ, Lehtimäki T, Lemire M, Lokki ML, Loley C, Luan J, Mangino M, Mateo Leach I, Medland SE, Mihailov E, Montgomery GW, Navis G, Newnham J, Nieminen MS, Palotie A, Panoutsopoulou K, Peters A, Pirastu N, Polasek O, Rehnström K, Ripatti S, Ritchie GR, Rivadeneira F, Robino A, Samani NJ, Shin SY, Sinisalo J, Smit JH, Soranzo N, Stolk L, Swinkels DW, Tanaka T, Teumer A, Tönjes A, Traglia M, Tuomilehto J, Valsesia A, van Gilst WH, van Meurs JB, Smith AV, Viikari J, Vink JM, Waeber G, Warrington NM, Widen E, Willemsen G, Wright AF, Zanke BW, Zgaga L; Wellcome Trust Case Control Consortium (WTCCC), Boehnke M, d'Adamo AP, de Geus E, Demerath EW, den Heijer M, Eriksson JG, Ferrucci L, Gieger C, Gudnason V, Hayward C, Hengstenberg C, Hudson TJ, Järvelin MR, Kogevinas M, Loos RJ, Martin NG, Metspalu A, Pennell CE, Penninx BW, Perola M, Raitakari O, Salomaa V, Schreiber S, Schunkert H, Spector TD, Stumvoll M, Uitterlinden AG, Ulivi S, van der Harst P, Vollenweider P, Völzke H, Wareham NJ, Wichmann HE, Wilson JF, Rudan I, Xue Y, Zeggini E. (literal)
Pagina inizio
  • 4805 (literal)
Pagina fine
  • 4815 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 21 (literal)
Rivista
Note
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 2Department of Medical Biology, 3Department for Research in Biomedicine and Health and 4Department of Public Health, University of Split School of Medicine, Split, Croatia, 5Institute of Genetics and Biophysics 'A. Buzzati-Traverso', National Research Council (CNR), Naples, Italy, 6Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia, 7Wellcome Trust Centre for Human Genetics and 8Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, UK, 9Genetics of Complex Traits, Peninsula Medical School, University of Exeter, UK, 10Department of Twin Research and Genetic Epidemiology, King's College London, London, UK, 11Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy, 12Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, 13School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, Australia, 14Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy, 15Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA, 16University of Cambridge Metabolic Research Labs and 17MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK, 18Department of Medical Genetics, University of Lausanne, Switzerland, 19Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, Lausanne, Switzerland, 20Department of Prosthetic Dentistry, Gerostomatology and Dental Materials and 21Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany, 22Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands, 23Centre for Population Health Sciences, University of Edinburgh, Scotland, UK, 24Universität zu Lübeck, Medizinische Klinik II, Lübeck, Germany, 25Deutsches Zentrum für Herz-Kreislauf-Forschung e. V. (DZHK) and 26Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Lübeck, Germany, 27Estonian Genome Center and 28Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia, 29Estonian Biocenter, Tartu, Estonia, 30Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA, 31Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo' - Trieste, University of Trieste, Italy, 32Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, 33CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain, 34Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA, 35Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA, 36Public Health and Gender Studies, Institute of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany, 37Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, 38Department of Epidemiology and 39Department of Internal Medicine, Erasmus MC Rotterdam, The Netherlands, 40Netherlands Consortium of Healthy Ageing, Rotterdam, The Netherlands, 41Department of Biostatistics and 42Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA, 43National Institute for Health and Welfare, Department of Chronic Disease Prevention, Population Studies Unit, Turku, Finland, 44Department of Clinical Physiology and 45Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere, Tampere, Finland, 46Tampere University Hospital, Tampere, Finland, 47Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK, 48Department of Epidemiology, Biostatistics and HTA & Department of Urology, 49Department of Laboratory Medicine, 50Department of Endocrinology and 51Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, 52Unit for Molecular Epidemiology and 53Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, 54Swiss Institute of Bioinformatics, Lausanne, Switzerland, 55Ontario Institute for Cancer Research, Toronto, Canada, 56Transplantation Laboratory, Haartman Institute and 57Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, 58Department of Cardiology, 59Department of Internal Medicine and 60Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, 61Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, Helsinki, Finland, 62Department of Medical Genetics, University and University Central Hospital of Helsinki, Helsinki, Finland, 63The Broad Institute of MIT and Harvard, Cambridge, USA, 64European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, 65Department of Cardiovascular Sciences, University of Leicester, Leicester, UK, 66Department of Psychiatry, EMGO Institute, Center for Neurogenomic and Cognitive Research and 67Department of Psychiatry, EMGO Institute, Institute for Neurosciences, VU University Medical Centre, Amsterdam, The Netherlands, 68Clinical Research Branch, National Institute of Aging, National Institute on Aging, Baltimore MD 21250, USA, 69Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany, 70Department of Medicine and 71IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany, 72Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki 00271, Finland, 73South Ostrobothnia Central Hospital, Seinäjoki 60220, Finland, 74Red RECAVA Grupo RD06/0014/0015, Hospital Universitario La Paz, Madrid 28046, Spain, 75Centre for Vascular Prevention, Danube-University Krems, Krems 3500, Austria, 76Ludwig Institute for Cancer Research, Lausanne, Switzerland, 77Icelandic Heart Association, Kopavogur, Iceland, 78University of Iceland, Reykjavik, Iceland, 79Department of Medicine and 80Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland, 81Turku University Hospital, Turku, Finland, 82Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, 83MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK, 84Ottawa Hospital Research Institute, Ottawa, Canada, 85Andrija Stampar School of Public Health, School of Medicine, University of Zagreb, Croatia, 86Division of Epidemiology & Community Health, University of Minnesota, MN, USA, 87Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit and 88Department of Chronic Disease Prevention, Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, Finland, 89Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland, 90University Central Hospital, Unit of General Practice, Helsinki, Finland, 91Folkhalsan Research Centre, Helsinki, Finland, 92Vasa Central Hospital, Vasa, Finland, 93Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA, 94Klinik und Poliklinik für Innere Medizin II, Regensburg, Germany, 95Departments of Medical Biophysics and Molecular Genetics, University of Toronto, Toronto, Canada, 96Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK, 97Institute of Health Sciences and 98Biocenter Oulu, University of Oulu, Oulu, Finland, 99National Institute for Health and Welfare, Oulu, Finland, 100IMIM (Hospital del Mar Research Institute), Barcelona, Spain, 101National School of Public Health, Athens, Greece, 102Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands, 103The Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland, 104Institut für Klinische Molekularbiologie, Christian-Albrechts Universität, Kiel, Germany, 105Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy, 106Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany, 107Klinikum Grosshadern, Munich, Germany (literal)
Titolo
  • Genome-wide meta-analysis of common variant differences between men and women. (literal)
Abstract
  • The male-to-female sex ratio at birth is constant across world populations with an average of 1.06 (106 male to 100 female live births) for populations of European descent. The sex ratio is considered to be affected by numerous biological and environmental factors and to have a heritable component. The aim of this study was to investigate the presence of common allele modest effects at autosomal and chromosome X variants that could explain the observed sex ratio at birth. We conducted a large-scale genome-wide association scan (GWAS) meta-analysis across 51 studies, comprising overall 114 863 individuals (61 094 women and 53 769 men) of European ancestry and 2 623 828 common (minor allele frequency >0.05) single-nucleotide polymorphisms (SNPs). Allele frequencies were compared between men and women for directly-typed and imputed variants within each study. Forward-time simulations for unlinked, neutral, autosomal, common loci were performed under the demographic model for European populations with a fixed sex ratio and a random mating scheme to assess the probability of detecting significant allele frequency differences. We do not detect any genome-wide significant (P < 5 × 10(-8)) common SNP differences between men and women in this well-powered meta-analysis. The simulated data provided results entirely consistent with these findings. This large-scale investigation across ~115 000 individuals shows no detectable contribution from common genetic variants to the observed skew in the sex ratio. The absence of sex-specific differences is useful in guiding genetic association study design, for example when using mixed controls for sex-biased traits. (literal)
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