Fabrication of PP-g-PEGMA-g-heparin and its hemocompatibility: From protein adsorption to anticoagulant tendency (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Fabrication of PP-g-PEGMA-g-heparin and its hemocompatibility: From protein adsorption to anticoagulant tendency (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.msec.2012.04.057 (literal)

Alternative label

• Jin J.; Jiang W.; Shi Q.; Zhao J.; Yin J.-H.; Stagnaro P. (2012)
  Fabrication of PP-g-PEGMA-g-heparin and its hemocompatibility: From protein adsorption to anticoagulant tendency
  in Applied surface science
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Jin J.; Jiang W.; Shi Q.; Zhao J.; Yin J.-H.; Stagnaro P. (literal)

Pagina inizio

• 5841 (literal)

Pagina fine

• 5849 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://ac.els-cdn.com/S0169433212003583/1-s2.0-S0169433212003583-main.pdf?_tid=7ed7224c-24e7-11e2-aa74-00000aab0f01&acdnat=1351858925_eed0e6337c887afa963880b9597af08f (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 258 (literal)

Rivista

• Applied surface science (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 15 (literal)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• J. Jin; W. Jiang; Q. Shi; J. Zhao; J.-H. Yin CIAC-CAS (P.R. China) P. Stagnaro ISMAC-CNR Genova (literal)

Titolo

• Fabrication of PP-g-PEGMA-g-heparin and its hemocompatibility: From protein adsorption to anticoagulant tendency (literal)

Abstract

• We described a two-step process to fabricate the heparinized polypropylene (PP) film using cyanuric chloride (CC) as a trifunctional reagent and poly (ethylene glycol) methacrylate (PEGMA) as a spacer. The modified PP films were characterized by attenuated total reflectance FT-IR and X-ray photoelectron spectroscopy; the content of PEGMA and heparin were determined by gravimetric method and a toluidine blue assay, respectively. For the PP-g-PEGMA films, it was found that small size protein BSA tended to adsorb on the surface of low molecular weight monomer grafted PP, whereas big spindle-shaped fibrinogen tended to adsorb on the surface of high molecular weight monomer grafted PP. We gave a definition of anti-protein adsorptive factor r with two model proteins, albumin and fibrinogen. The results by platelet adhesion and plasma recalcification time (PRT) experiments indicated that the factor r could be used to quantitatively evaluate the anticoagulant tendency of PP-g-PEGMA modified films. For the PP-g-PEGMA-g-heparin modified films, the surface was proved to have a high bioactivity by the adsorption of AT III assay and very low platelet adhesion. It indicated that immobilization of heparin on the PP film with PEGMA as a spacer was an effective way to improve the hemocompatibility of PP. (literal)

Prodotto di

• Istituto per lo studio delle macromolecole (ISMAC) (Istituto)
• Progettazione e sviluppo di materiali polimerici multifasici micro e nanostrutturati (PM.P02.005.004) (Modulo)

Autore CNR

• PAOLA STAGNARO (Persona)

Insieme di parole chiave

• Parole chiave di "Fabrication of PP-g-PEGMA-g-heparin and its hemocompatibility: From protein adsorption to anticoagulant tendency" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto per lo studio delle macromolecole (ISMAC) (Istituto)
• Progettazione e sviluppo di materiali polimerici multifasici micro e nanostrutturati (PM.P02.005.004) (Modulo)

Autore CNR di

• PAOLA STAGNARO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Applied surface science (Rivista)

Insieme di parole chiave di

• Parole chiave di "Fabrication of PP-g-PEGMA-g-heparin and its hemocompatibility: From protein adsorption to anticoagulant tendency" (Insieme di parole chiave)