http://www.cnr.it/ontology/cnr/individuo/prodotto/ID189470

Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function (Articolo in rivista) (literal)

Anno

2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1371/journal.pgen.1002584 (literal)

Alternative label

Pattaro C, Köttgen A, Teumer A, Garnaas M, Böger CA, Fuchsberger C, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, O'Seaghdha CM, Glazer N, Isaacs A, Liu CT, Smith AV, O'Connell JR, Struchalin M, Tanaka T, Li G, Johnson AD, Gierman HJ, Feitosa M, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson Å, Tönjes A, Dehghan A, Chouraki V, Holliday EG, Sorice R, Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Kollerits B, Pistis G; CARDIoGRAM Consortium; ICBP Consortium; CARe Consortium; Wellcome Trust Case Control Consortium 2 (WTCCC2), Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Cavalieri M, Rao M, Hu FB, Demirkan A, Oostra BA, de Andrade M, Turner ST, Ding J, Andrews JS, Freedman BI, Koenig W, Illig T, Döring A, Wichmann HE, Kolcic I, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Endlich K, Ernst F, Homuth G, Kroemer HK, Nauck M, Stracke S, Völker U, Völzke H, Kovacs P, Stumvoll M, Mägi R, Hofman A, Uitterlinden AG, Rivadeneira F, Aulchenko YS, Polasek O, Hastie N, Vitart V, Helmer C, Wang JJ, Ruggiero D, Bergmann S, Kähönen M, Viikari J, Nikopensius T, Province M, Ketkar S, Colhoun H, Doney A, Robino A, Giulianini F, Krämer BK, Portas L, Ford I, Buckley BM, Adam M, Thun GA, Paulweber B, Haun M, Sala C, Metzger M, Mitchell P, Ciullo M, Kim SK, Vollenweider P, Raitakari O, Metspalu A, Palmer C, Gasparini P, Pirastu M, Jukema JW, Probst-Hensch NM, Kronenberg F, Toniolo D, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Siscovick DS, van Duijn CM, Borecki I, Kardia SL, Liu Y, Curhan GC, Rudan I, Gyllensten U, Wilson JF, Franke A, Pramstaller PP, Rettig R, Prokopenko I, Witteman JC, Hayward C, Ridker P, Parsa A, Bochud M, Heid IM, Goessling W, Chasman DI, Kao WH, Fox CS. (2012)
Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function
in PLOS genetics; Public Library of Science, San Francisco (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Pattaro C, Köttgen A, Teumer A, Garnaas M, Böger CA, Fuchsberger C, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, O'Seaghdha CM, Glazer N, Isaacs A, Liu CT, Smith AV, O'Connell JR, Struchalin M, Tanaka T, Li G, Johnson AD, Gierman HJ, Feitosa M, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson Å, Tönjes A, Dehghan A, Chouraki V, Holliday EG, Sorice R, Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Kollerits B, Pistis G; CARDIoGRAM Consortium; ICBP Consortium; CARe Consortium; Wellcome Trust Case Control Consortium 2 (WTCCC2), Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Cavalieri M, Rao M, Hu FB, Demirkan A, Oostra BA, de Andrade M, Turner ST, Ding J, Andrews JS, Freedman BI, Koenig W, Illig T, Döring A, Wichmann HE, Kolcic I, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Endlich K, Ernst F, Homuth G, Kroemer HK, Nauck M, Stracke S, Völker U, Völzke H, Kovacs P, Stumvoll M, Mägi R, Hofman A, Uitterlinden AG, Rivadeneira F, Aulchenko YS, Polasek O, Hastie N, Vitart V, Helmer C, Wang JJ, Ruggiero D, Bergmann S, Kähönen M, Viikari J, Nikopensius T, Province M, Ketkar S, Colhoun H, Doney A, Robino A, Giulianini F, Krämer BK, Portas L, Ford I, Buckley BM, Adam M, Thun GA, Paulweber B, Haun M, Sala C, Metzger M, Mitchell P, Ciullo M, Kim SK, Vollenweider P, Raitakari O, Metspalu A, Palmer C, Gasparini P, Pirastu M, Jukema JW, Probst-Hensch NM, Kronenberg F, Toniolo D, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Siscovick DS, van Duijn CM, Borecki I, Kardia SL, Liu Y, Curhan GC, Rudan I, Gyllensten U, Wilson JF, Franke A, Pramstaller PP, Rettig R, Prokopenko I, Witteman JC, Hayward C, Ridker P, Parsa A, Bochud M, Heid IM, Goessling W, Chasman DI, Kao WH, Fox CS. (literal)

Pagina inizio

e1002584 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

8 (literal)

Rivista

PLOS genetics (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

3 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1. Univ Lubeck, European Acad Bozen Bolzano EURAC, Inst Med Genet, Bolzano, Italy 2. Univ Lubeck, Affiliated Inst, Bolzano, Italy 3. Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA 4. Freiburg Univ Clin, Div Renal, Freiburg, Germany 5. Ernst Moritz Arndt Univ Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany 6. Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Div Genet, Boston, MA 02115 USA 7. Univ Med Ctr Regensburg, Dept Internal Med 2, Regensburg, Germany 8. Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA 9. Univ Hosp Regensburg, Dept Internal Med 2, Regensburg, Germany 10. Regensburg Univ Med Ctr, Dept Epidemiol & Prevent Med, Regensburg, Germany 11. Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA 12. Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA 13. Washington Univ, Sch Med, Div Stat Genom, St Louis, MO USA 14. Univ Hosp Regensburg, Dept Epidemiol & Prevent Med, Regensburg, Germany 15. German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 1, Neuherberg, Germany 16. NHLBI, Framingham Heart Study, Framingham, MA USA 17. Ctr Populat Studies, Framingham, MA USA 18. Brigham & Womens Hosp, Div Nephrol, Boston, MA 02115 USA 19. Harvard Univ, Sch Med, Channing Lab, Boston, MA 02115 USA 20. Boston Univ, Sch Med, Dept Med, Sect Prevent Med & Epidemiol, Boston, MA 02118 USA 21. Erasmus Univ, Med Ctr, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands 22. Ctr Med Syst Biol, Leiden, Netherlands 23. Iceland Heart Assoc, Res Inst, Kopavogur, Iceland 24. Univ Iceland, Reykjavik, Iceland 25. Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA 26. Erasmus Univ, Dept Epidemiol & Biostat, Med Ctr, NL-3000 DR Rotterdam, Netherlands 27. Erasmus Univ, Dept Forens Mol Biol, Med Ctr, Rotterdam, Netherlands 28. NIA, Clin Res Branch, Baltimore, MD 21224 USA 29. Univ Washington, Seattle, WA 98195 USA 30. Stanford Univ, Dept Dev Biol, Stanford, CA 94305 USA 31. Mayo Clin, Div Biomed Stat & Informat, Rochester, MN USA 32. Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA 33. Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA 34. Uppsala Univ, Rudbeck Lab, Uppsala, Sweden 35. Univ Leipzig, Dept Med, Leipzig, Germany 36. Univ Leipzig, IFB Adipos Dis, Leipzig, Germany 37. Inst Pasteur, Inserm UMR744, F-59019 Lille, France 38. Univ Newcastle, Sch Med & Publ Hlth, Ctr Clin Epidemiol & Biostat, Newcastle, NSW 2300, Australia 39. Hunter Med Res Inst, Ctr Informat Based Med, Newcastle, NSW, Australia 40. Inst Genet & Biophys Adriano Buzzati Traverso CNR, Naples, Italy 41. Univ Lausanne, Dept Med Genet, Lausanne, Switzerland 42. Swiss Inst Bioinformat, Lausanne, Switzerland 43. Univ Tampere, Dept Clin Chem, FIN-33101 Tampere, Finland 44. Tampere Univ Hosp, Ctr Lab Med Tampere Finn Medi 2, Tampere, Finland 45. EGCUT, Tartu, Estonia 46. Univ Tartu, Estonian Bioctr, EE-50090 Tartu, Estonia 47. Univ Tartu, Inst Mol & Cell Biol, EE-50090 Tartu, Estonia 48. Univ Dundee, Clin Res Ctr, Ninewells Hosp, Wellcome Trust Ctr Mol Med,NHS Tayside, Dundee, Scotland 49. Inst Maternal & Child Hlth IRCCS Burlo Garofo, Trieste, Italy 50. Inst Populat Genet CNR, Sassari, Italy 51. Leiden Univ, Dept Cardiol, Med Ctr, Leiden, Netherlands 52. Swiss Trop & Publ Hlth Inst, Unit Chron Dis Epidemiol, Basel, Switzerland 53. Innsbruck Med Univ, Div Genet Epidemiol, Innsbruck, Austria 54. Ist Sci San Raffaele, Div Genet & Cell Biol, I-20132 Milan, Italy 55. NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA 56. Univ Texas Hlth Sci Ctr, Ctr Human Genet, Houston, TX USA 57. Med Univ Graz, Austrian Stroke Prevent Study, Inst Mol Biol & Biochem, Graz, Austria 58. Med Univ Graz, Dept Neurol, Graz, Austria 59. Med Univ Graz, Austrian Stroke Prevent Study, Univ Clin Neurol, Dept Special Neurol, Graz, Austria 60. Tufts Univ, Sch Med, Tufts Med Ctr, Tufts Evidence Practice Ctr,Div Nephrol, Boston, MA 02111 USA 61. Mayo Clin, Dept Internal Med, Div Nephrol & Hypertens, Rochester, MN USA 62. Wake Forest Sch Med, Dept Internal Med Geriatr, Winston Salem, NC USA 63. Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC USA 64. Wake Forest Sch Med, Dept Internal Med, Winston Salem, NC USA 65. Univ Ulm Klinikum, Abt Innere 2, Ulm, Germany 66. German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany 67. Univ Munich, Inst Med Informat Biometry & Epidemiol, Munich, Germany 68. Klinikum Grosshadern, Neuherberg, Germany 69. Univ Split, Sch Med, Croatian Ctr Global Hlth, Split, Croatia 70. Stanford Univ, Dept Genet, Stanford, CA 94305 USA 71. Univ Chicago, Dept Med, Chicago, IL 60637 USA 72. Univ Edinburgh, Sch Med, Ctr Populat Hlth Sci, Edinburgh, Midlothian, Scotland 73. Western Gen Hosp, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland 74. Univ Kiel, Inst Clin Mol Biol, Kiel, Germany 75. Univ Hosp Schleswig Holstein, Popgen Biobank, Kiel, Germany 76. Ernst Moritz Arndt Univ Greifswald, Clin Prosthodont Dent Gerostomatol & Mat Sci, Greifswald, Germany 77. Ernst Moritz Arndt Univ Greifswald, Inst Anat & Cell Biol, Greifswald, Germany 78. Ernst Moritz Arndt Univ Greifswald, Inst Pharmacol, Greifswald, Germany 79. Ernst Moritz Arndt Univ Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany 80. Ernst Moritz Arndt Univ Greifswald, Clin Internal Med A, Greifswald, Germany 81. Ernst Moritz Arndt Univ Greifswald, Inst Community Med, Greifswald, Germany 82. Univ Leipzig, Dept Med, Leipzig, Germany 83. Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England 84. Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England 85. Erasmus Univ, Med Ctr, Dept Internal Med, Rotterdam, Netherlands 86. Univ Split, Fac Med, Croatian Ctr Global Hlth, Split, Croatia 87. Univ Bordeaux 2, INSERM U897, ISPED, F-33076 Bordeaux, France 88. Univ Sydney, Westmead Hosp, Westmead Millennium Inst, Ctr Vis Res, Sydney, NSW 2006, Australia 89. Univ Melbourne, CERA, Melbourne, Vic, Australia 90. Univ Tampere, Dept Clin Physiol, FIN-33101 Tampere, Finland 91. Univ Turku, Dept Med, Turku, Finland 92. Univ Trieste, IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy 93. Univ Med Ctr Mannheim, Dept Med 5, Mannheim, Germany 94. Univ Glasgow, Robertson Ctr Biostat, Glasgow, Lanark, Scotland 95. Natl Univ Ireland Univ Coll Cork, Dept Pharmacol & Therapeut, Cork, Ireland 96. Paracelsus Med Univ, Dept Internal Med 1, Salzburg, Austria 97. Univ Paris 11, CESP Team 10, Inserm UMRS 1018, Villejuif, France 98. CHU Vaudois, Dept Internal Med, Lausanne, Switzerland 99. Univ Turku, Turku Univ Hosp, Dept Clin Physiol, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland 100. Univ Dundee, Ninewells Hosp & Med Sch, Biomed Res Inst, Dundee DD1 9SY, Scotland 101. ICIN, Utrecht, Netherlands 102. Einthoven Lab Expt Vasc Med, Leiden, Netherlands 103. Durrer Ctr Cardiogenet Res, Amsterdam, Netherlands 104. Vet Adm Med Ctr, Geriatr Res & Educ Clin Ctr, Baltimore, MD 21218 USA 105. Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD USA 106. Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA 107. Ernst Moritz Arndt Univ Greifswald, Inst Physiol, Greifswald, Germany 108. Univ Maryland, Sch Med, Div Nephrol, Baltimore, MD 21201 USA 109. Univ Lausanne, CH-1066 Epalinges, Switzerland 110. CHU Vaudois, Univ Inst Social & Prevent Med, Epalinges, Switzerland 111. Brigham & Womens Hosp, Dept Internal Med, Div Genet, Boston, MA USA 112. Brigham & Womens Hosp, Dept Internal Med, Div Gastroenterol, Boston, MA USA 113. Harvard Univ, Harvard Stem Cell Inst, Cambridge, MA 02138 USA 114. Brigham & Womens Hosp, Div Endocrinol, Boston, MA USA (literal)

Titolo

Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function (literal)

Abstract

Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genomewide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD. (literal)

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