Chelating Systems for Tc-99m/Re-188 in the Development of Radiolabeled Peptide Pharmaceuticals (Articolo in rivista)

Type
Label
  • Chelating Systems for Tc-99m/Re-188 in the Development of Radiolabeled Peptide Pharmaceuticals (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • Bolzati C.; Carta D.; Salvarese N.; Refosco F. (2012)
    Chelating Systems for Tc-99m/Re-188 in the Development of Radiolabeled Peptide Pharmaceuticals
    in Anti-cancer agents in medicinal chemistry (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Bolzati C.; Carta D.; Salvarese N.; Refosco F. (literal)
Pagina inizio
  • 428 (literal)
Pagina fine
  • 461 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.benthamdirect.com/98172/issue/5 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 12 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 5 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1,4 : ICIS-CNR, Corso Stati Uniti, 4, 35127 Padova, Italy 2,3 : Dept. of Pharmaceutical Sciences, University of Padua, Via Marzolo, 5, 35131 Padova, Italy (literal)
Titolo
  • Chelating Systems for Tc-99m/Re-188 in the Development of Radiolabeled Peptide Pharmaceuticals (literal)
Abstract
  • Currently, receptor based radiopharmaceuticals have received great attention in molecular imaging and radiotherapy of cancer, and provide a unique tool for target-specific delivery of radionuclides to pathological tissues. In this context, receptor binding peptides represent an attractive class of target vectors for Nuclear Medicine purposes. The rich chemistry of the group 7 elements elaborated in past years, has allowed the development of different procedures for the preparation of radiolabeled peptides in high yield. This, joint to the use of solid-phase peptide synthesis, has opened the possibility to explore new strategies for approaching the design of new class of radiolabeled receptor-targeted peptides, and to create new versatilities in targeting vehicle design e.g. in synthesis of metal-cyclized peptides or of multivalent targeting agents. This review provides an overview on several aspects of the development of new 99mTc/ 188Re-peptide based target specific radiopharmaceuticals, in particular on the synthetic strategies employed for modifying molecular vectors, and the application of the different metal-cores and/or building block for preparing high specific activity agents. (literal)
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