Transport of the anti-diabetic VO2+ complexes formed by pyrone derivatives in the blood serum (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Transport of the anti-diabetic VO2+ complexes formed by pyrone derivatives in the blood serum (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.jinorgbio.2012.04.020 (literal)

Alternative label

• D. Sanna; L. Bíró; P. Buglyó; G. Micera; E. Garribba (2012)
  Transport of the anti-diabetic VO2+ complexes formed by pyrone derivatives in the blood serum
  in Journal of inorganic biochemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• D. Sanna; L. Bíró; P. Buglyó; G. Micera; E. Garribba (literal)

Pagina inizio

• 87 (literal)

Pagina fine

• 99 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.sciencedirect.com/science/article/pii/S0162013412001420 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 115 (literal)

Rivista

• Journal of inorganic biochemistry (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto CNR di Chimica Biomolecolare, Trav. La Crucca 3, I-07040 Sassari, Italy Department of Inorganic and Analytical Chemistry, University of Debrecen, H-4010 Debrecen, Hungary Dipartimento di Chimica e Farmacia, and Centro Interdisciplinare per lo Sviluppo della Ricerca Biotecnologica e per lo Studio della Biodiversità della Sardegna, Università di Sassari, Via Vienna 2, I-07100 Sassari, Italy (literal)

Titolo

• Transport of the anti-diabetic VO2+ complexes formed by pyrone derivatives in the blood serum (literal)

Abstract

• The biotransformation in the blood serum of the two anti-diabetic agents [VO(ema)2] - or BEOV - and [VO(koj)2] formed by ethylmaltol (Hema) and kojic acid (Hkoj) was studied with EPR spectroscopy, pH-potentiometry and DFT calculations. For comparison, the behavior of the systems with tropolone (Htrop) was also analyzed. The interaction of [VO(ema)2] and [VO(koj)2] with the most important bioligands of the serum, lactic (Hlact) and citric acid (H3citr), human serum transferrin (hTf), human serum albumin (HSA) and immunoglobulin G (IgG) was examined and discussed. Among the several mixed species observed, cis-VO(carrier)2(hTf), cis-VO(carrier)2(HSA) and cis-VO(carrier)2(IgG), where carrier is ethylmaltolate or kojate, with a His-N of the protein coordinated in the equatorial position, are plausible candidates for the transport processes of the drug toward the target organs. The values of the log? are in the range 19.6-19.8 for the species formed by ethylmaltol and 17.4-17.6 for those formed by kojic acid. The formation of such species was confirmed through pH-titrations of the model systems VO2 +/carrier/1-MeIm and VO2 +/carrier/Ac-his, where 1-MeIm and Ac-his are 1-methylimidazole and N-acetylhistamine, and DFT calculations of 51V Az of the model species cis-[VO(carrier)2(1-MeIm)] and cis-[VO(carrier)2(Ac-his)]. The values of the stability constants for the mixed species observed were used to predict the biodistribution of VO2 + ion between the blood serum components for concentrations of 1, 10 and 50 ?M. (literal)

Prodotto di

• Caratterizzazione di complessi metallici formati da proteine coinvolte in patologie correlate al disordine conformazionale proteico. (PM.P01.004.002) (Modulo)
• Institute of biomolecular chemistry (ICB) (Istituto)

Autore CNR

• DANIELE SANNA (Unità di personale interno)

Incoming links:

Autore CNR di

• DANIELE SANNA (Unità di personale interno)

Prodotto

• Institute of biomolecular chemistry (ICB) (Istituto)
• Caratterizzazione di complessi metallici formati da proteine coinvolte in patologie correlate al disordine conformazionale proteico. (PM.P01.004.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of inorganic biochemistry (Rivista)