Imaging of proliferation in breast cancer with 18F-FDG PET: Correlation between partial volume corrected SUV and MiB-1 proliferation index (Abstract in rivista)

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Label
  • Imaging of proliferation in breast cancer with 18F-FDG PET: Correlation between partial volume corrected SUV and MiB-1 proliferation index (Abstract in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • Carla Canevari; Francesca Gallivanone; Paola Mapelli; Maria Picchio; Isabella Sassi; Veronica Zuber; Alberto Marassi; Cristina Messa; MariaCarla Gilardi; Isabella Castiglioni. (2012)
    Imaging of proliferation in breast cancer with 18F-FDG PET: Correlation between partial volume corrected SUV and MiB-1 proliferation index
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Carla Canevari; Francesca Gallivanone; Paola Mapelli; Maria Picchio; Isabella Sassi; Veronica Zuber; Alberto Marassi; Cristina Messa; MariaCarla Gilardi; Isabella Castiglioni. (literal)
Pagina inizio
  • Abstract 334 (literal)
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  • 53 (literal)
Rivista
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  • Supplemento (literal)
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  • Nuclear Medicine Department, Scientific Institute San Raffaele, Milan, Italy. IBFM-CNR, Segrate (MI), Italy. University of Milano-Bicocca, Milan, Italy. Pathology Department, San Raffaele Scientific Institute, Milan, Italy. Surgical Department, San Raffaele Scientific Institute, Milan, Italy. Nuclear Medicine Department, San Gerardo Hospital; Tecnomed Foundation, University of Milano-Bicocca, Monza, Italy. LATO s.r.l, Cefalù (PA), Italy. (literal)
Titolo
  • Imaging of proliferation in breast cancer with 18F-FDG PET: Correlation between partial volume corrected SUV and MiB-1 proliferation index (literal)
Abstract
  • Objectives: To assess the role of 18F-FDG quantification with Partial Volume Correction (PVC) as potential marker for MiB-1 proliferation index in breast cancer. Methods: An integrated protocol was developed involving 43 oncological patients with breast cancer. All patients underwent a 18F-FDG PET-CT study before surgery. Patient weight, injected dose and residual were measured. Averaged Body-Weight Standardized Uptake Value with correction for Partial Volume Effect (PVC-SUVBW) was calculated. After surgery, excised tissues were sectioned and classified according to the WHO guidelines, evaluating MiB-1 index. A cut-off of 18% for MiB-1 proliferation index allowed to divide the patients in two groups. Mann-Whitney test was used to evaluate the differences between the two groups with respect to the PVC-SUVBW. Univariate linear regression was also applied. Results: SUV strongly correlated with MiB-1 proliferation index (p < 0.001), in particular PVC-SUV =9.19±6.28 g/cc for tumor with an expression of MiB-1 18%, while PVC-SUV = 4.00 ± 2.29 for tumor with an expression of MiB-1<18%. Linear univariate regression confirmed that the relationship between MiB-1 proliferation index and in vivo SUV biomarker. Conclusions: A strong correlation between SUV and MiB-1 proliferation index was found, suggesting that SUV can be evaluated as a surrogate of marker of proliferation (literal)
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