Role of FDG PET/CT in the preoperative staging of high-risk clinical early stage endometrial cancer (Abstract/Poster in rivista)

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  • Role of FDG PET/CT in the preoperative staging of high-risk clinical early stage endometrial cancer (Abstract/Poster in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
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  • Cinzia Crivellaro; Luca Guerra; Mauro Signorelli; Paola Mapelli; Elena De Ponti; Maria Picchio; Cecilia Pirovano; Rodolfo Milani; Cristina Messa. (2012)
    Role of FDG PET/CT in the preoperative staging of high-risk clinical early stage endometrial cancer
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  • Cinzia Crivellaro; Luca Guerra; Mauro Signorelli; Paola Mapelli; Elena De Ponti; Maria Picchio; Cecilia Pirovano; Rodolfo Milani; Cristina Messa. (literal)
Pagina inizio
  • Abstract 64 (literal)
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  • 53 (literal)
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  • Supplemento (literal)
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  • Abstract (literal)
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  • Nuclear Medicine, University Milano-Bicocca, Milano, Italy. Nuclear Medicine, San Gerardo Hospital, Monza, Italy. Gynecology, San Gerardo Hospital, Monza, Italy. Medical Physics, San Gerardo Hospital, Monza, Italy. Nuclear Medicine, San Raffaele Scientific Institute, IBFM-CNR, Milano, Italy. Nuclear Medicine, San Gerardo Hospital, Monza, Tecnomed Foundation, University Milano-Bicocca, IBFM-CNR, Milano, Italy (literal)
Titolo
  • Role of FDG PET/CT in the preoperative staging of high-risk clinical early stage endometrial cancer (literal)
Abstract
  • Objectives: To evaluate: a) the role of FDG PET/CT in the preoperative N-staging of high-risk clinical stage I endometrial cancer; b) the correlation between the metabolic characteristics of endometrial tumor uptake and the presence of lymph-node (LN) metastases. Methods: Sixty-eight high-risk (G2 with deep myometrial invasion, G3, serous and clear-cell carcinoma) clinical stage I endometrial cancer patients (pts) (61.2±13.1 years) underwent preoperative PET/CT scan followed by total hysterectomy, bilateral salpingo-oophorectomy and systematic pelvic lymphadenectomy. PET/CT images were retrospectively analyzed and correlated to histological findings. Maximal and mean standardized uptake value (SUVmax, SUVmean), metabolic tumor volume (MTV), total lesion glycolysis (TLG) of endometrial lesions were calculated. Results: PET/CT resulted negative at pelvic LNs in 58/68 pts (57 TN, 1 FN) and positive in 10/68 pts (9 TP, 1 FP). On pt-based analysis, sensitivity, specificity, accuracy, negative and positive predictive value of PET/CT in detecting pelvic LN metastases were 90%, 98%, 97%, 98%, 90%, respectively. A significant correlation was found between the presence of LN metastases and SUVmax (p=0.03), MTV (p=0.01), TLG (p=0.004) of the primary tumor, respectively, while no significant correlation was obtained for SUVmean. Conclusions: In high-risk clinical stage I endometrial cancer: a) FDG PET/CT is an accurate tool for the nodal status assessment. Its high negative predictive value (98%) could be useful in selecting pts who may benefit from lymphadenectomy; b) SUVmax, MTV and TLG of the primary tumor are significantly correlated to LN metastases (literal)
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