Added diagnostic value of respiratory gated (4D) PET/CT in detection of neoplastic liver lesions (Abstract in rivista)

Type
Label
  • Added diagnostic value of respiratory gated (4D) PET/CT in detection of neoplastic liver lesions (Abstract in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Alternative label
  • Federica Elisei; Luca Guerra; Elena De Ponti; Sabrina Morzenti; Alessandra Zorz; Cinzia Crivellaro; Cristina Messa. (2012)
    Added diagnostic value of respiratory gated (4D) PET/CT in detection of neoplastic liver lesions
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Federica Elisei; Luca Guerra; Elena De Ponti; Sabrina Morzenti; Alessandra Zorz; Cinzia Crivellaro; Cristina Messa. (literal)
Pagina inizio
  • Abstract 1234 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 53 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • Supplemento (literal)
Note
  • Abstract (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Nuclear Medicine, San Gerardo Hospital, Monza, Italy. Medical Physics, San Gerardo Hospital, Monza, Italy. Nuclear Medicine, University of Milano-Bicocca, Milano, Italy. Nuclear Medicine, Tecnomed Foundation, University of Milano-Bicocca, IBFM-CNR, Milano, Italy. (literal)
Titolo
  • Added diagnostic value of respiratory gated (4D) PET/CT in detection of neoplastic liver lesions (literal)
Abstract
  • Objectives: To evaluate the diagnostic value of 4D PET/CT compared to standard (3D) PET/CT in neoplastic liver lesions. Methods: 36 liver lesions in 25 oncologic patients (15 females, 10 males, mean +/- SD age 65 +/-8.5) submitted to 3D and 4D scan (Discovery 600 - GE Healthcare - Milwaukee; WI-US) were prospectively analysed. 3D and 4D datasets were independently evaluated by two nuclear medicine physicians aware of patients' clinical status at the moment of the scan. Both in 3D and 4D scan, SUVmax values were recorded in equivocal and positive lesions while in negative lesions SUVmax was not calculated and the lesions were defined as \"no uptake\". Image analysis was performed by scoring the lesions as positive, negative or equivocal according to visual criteria by comparing the lesion's uptake to the liver background activity. Analysis results were then compared with clinical follow-up as standard reference for both techniques. Results: Mean +/- SD SUVmax values in 3D and 4D scans were 4.3 +/- 1.3 and 5.9 +/- 2.1 (p = 0.001). In 3D visual analysis, 20/36 (55.6%) lesions were scored positive, 6/36 (16.7%) negative and 10/36 (27.8%) equivocal. The same figures for 4D scan were 31/36 (86.1%), 5/36 (13.9%) and no equivocal lesions. Regarding the 3D and 4D discordant results, 1/36 (2.8%) 3D negative and 10/36 (27.8%) 3D equivocal lesions were scored positive in 4D. According to follow-up data available in 34 lesions, 4D scan was TP in 28/34 (82.3%), TN in 5/34 (14.7%) and FP in 1/34 (2.9%). 4D diagnostic accuracy in neoplastic lesions' detection was 96.5%. Conclusions: Our preliminary data showed that 4D PET/CT is very accurate in the detection of neoplastic lesions located in the liver and can reduce the frequency of undetermined findings in standard 3D sca (literal)
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it