The N-acetylcysteine-insensitive acetic acid-induced yeast programmed cell death occurs without macroautophagy (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• The N-acetylcysteine-insensitive acetic acid-induced yeast programmed cell death occurs without macroautophagy (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Alternative label

• Antonacci L; Guaragnella N; Zdralevic M; Passarella S; Marra E and Giannattasio S. (2012)
  The N-acetylcysteine-insensitive acetic acid-induced yeast programmed cell death occurs without macroautophagy
  in Current pharmaceutical biotechnology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Antonacci L; Guaragnella N; Zdralevic M; Passarella S; Marra E and Giannattasio S. (literal)

Pagina inizio

• 2705 (literal)

Pagina fine

• 2711 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 13 (literal)

Rivista

• Current pharmaceutical biotechnology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR - Istituto di Biomembrane e Bioenergetica, I-70126 Bari, Italy; Dipartimento di Medicina e Scienze per la Salute, Università del Molise, I-86100 Campobasso, Italy (literal)

Titolo

• The N-acetylcysteine-insensitive acetic acid-induced yeast programmed cell death occurs without macroautophagy (literal)

Abstract

• Programmed cell death can occur through two separate pathways caused by treatment of Saccharomyces cerevisiae with acetic acid (AA-PCD), which differ from one another essentially with respect to their sensitivity to Nacetylcysteine (NAC) and to the role played by cytochrome c and metacaspase YCA1. Moreover, yeast can also undergo macroautophagy which occurs in NAC-insensitive manner. In order to gain some insight into the relationship between AA-PCD and macroautophagy use was made of WT and knock-out cells lacking YCA1 and/or cytochrome c. We show that i. macroautophagy is modulated by YCA1 and by cytochrome c in a negative and positive manner, respectively, ii. the NAC-insensitive AA-PCD and macroautophagy differ from one another and iii. NAC-insensitive AA-PCD pathway takes place essentially without macroautophagy, even if the shift of extracellular pH to acidic values required for AA-PCD to occur leads itself to increased or decreased macroautophagy in YCA1 or cytochrome c-lacking cells. (literal)

Prodotto di

• Interrelazione nucleo/citoplasma/mitocondri nell'omeostasi cellulare. (SV.P15.003.001) (Modulo)
• Istituto di biomembrane e bioenergetica (IBBE) (Istituto)

Autore CNR

• SERGIO GIANNATTASIO (Persona)
• ERSILIA MARRA (Unità di personale interno)
• NICOLETTA GUARAGNELLA (Unità di personale interno)
• Masa Zdralevic (Persona)

Insieme di parole chiave

• Keywords of "The N-acetylcysteine-insensitive acetic acid-induced yeast programmed cell death occurs without macroautophagy" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di biomembrane e bioenergetica (IBBE) (Istituto)
• Interrelazione nucleo/citoplasma/mitocondri nell'omeostasi cellulare. (SV.P15.003.001) (Modulo)

Autore CNR di

• SERGIO GIANNATTASIO (Persona)
• ERSILIA MARRA (Unità di personale interno)
• Masa Zdralevic (Persona)
• NICOLETTA GUARAGNELLA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Current pharmaceutical biotechnology (Rivista)

Insieme di parole chiave di

• Keywords of "The N-acetylcysteine-insensitive acetic acid-induced yeast programmed cell death occurs without macroautophagy" (Insieme di parole chiave)