http://www.cnr.it/ontology/cnr/individuo/prodotto/ID188195

[(11)C]-MP4A PET cholinergic measurements in amnestic mild cognitive impairment, probable Alzheimer's disease, and dementia with Lewy bodies: a Bayesian method and voxel-based analysis (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

[(11)C]-MP4A PET cholinergic measurements in amnestic mild cognitive impairment, probable Alzheimer's disease, and dementia with Lewy bodies: a Bayesian method and voxel-based analysis (Articolo in rivista) (literal)

Anno

2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.3233/JAD-2012-111748 (literal)

Alternative label

Alessandra Marcone; Valentina Garibotto; Rosa Maria Moresco; Ioana Florea; Andrea Panzacchi; Assunta Carpinelli; Jere R. Virta; Marco Tettamanti; Barbara Borroni; Alessandro Padovani; Alessandra Bertoldo; Karl Herholz; Juha O. Rinne; Stefano Francesco Cappa; Daniela Perani. (2012)
[(11)C]-MP4A PET cholinergic measurements in amnestic mild cognitive impairment, probable Alzheimer's disease, and dementia with Lewy bodies: a Bayesian method and voxel-based analysis
in Journal of Alzheimer's disease
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Alessandra Marcone; Valentina Garibotto; Rosa Maria Moresco; Ioana Florea; Andrea Panzacchi; Assunta Carpinelli; Jere R. Virta; Marco Tettamanti; Barbara Borroni; Alessandro Padovani; Alessandra Bertoldo; Karl Herholz; Juha O. Rinne; Stefano Francesco Cappa; Daniela Perani. (literal)

Rivista

Journal of Alzheimer's disease (Rivista)

Note

PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Clinical Neurosciences Department, San Raffaele Turro Hospital, San Raffaele Scientific Institute, Milan, Italy. Vita Salute San Raffaele University, Milan, Italy. Nuclear Medicine Department, San Raffaele Scientific Institute Milan, Milan, Italy. IBFM-CNR, Milan, Italy. Turku PET Centre, University of Turku, Turku, Finland. Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, University of Brescia, Brescia, Italy. Department of Information Engineering, University of Padua, Padua, Italy. Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom. University of Milan-Bicocca, Milan, Italy (literal)

Titolo

[(11)C]-MP4A PET cholinergic measurements in amnestic mild cognitive impairment, probable Alzheimer's disease, and dementia with Lewy bodies: a Bayesian method and voxel-based analysis (literal)

Abstract

Non-invasive approaches for positron emission tomography (PET) parametric imaging of acetylcholinesterase (AChE) activity have been developed and applied to the investigation of dementia, mainly Alzheimer's disease (AD), but also dementia with Lewy bodies (DLB), not including, however, patients in the early disease stage. The few cholinergic PET studies on mild cognitive impairment (MCI) did not provide clinical follow-up. One limitation of the methods used so far is the relatively low sensitivity in measuring subcortical or deep cortical structures, which might represent specific disease markers. Here we assessed AChE activity with [11C]-MP4A and PET by a maximum a posteriori Bayesian method (MAPB) based on a 2-tissue compartment-3-rate-constant reference region model. 30 subjects were included: 10 multi-domain amnestic MCI (aMCI) with a follow up of 2 years, 7 probable AD (pAD), 4 DLB subjects, and 9 healthy controls. Regions of interest and voxel-based statistical parametric mapping analyses revealed significant and widespread AChE reductions in several cortical regions and in the hippocampus in all pAD subjects and aMCI subjects who progressed to AD (converters). Noteworthy, hippocampal AChE activity correlated significantly with long-term verbal and non-verbal memory in both aMCI converters and pAD. The pattern was more heterogeneous in early DLB patients, with only 2 out of 4 cases showing a severe or intermediate reduction of AChE activity. The comparable AChE reductions in pAD and aMCI converters indicate the presence of a widespread impairment of the cholinergic system already in the MCI phase. A more variable degree of cholinergic dysfunction is present in early DLB. (literal)

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