Interaction between combustion-generated organic nanoparticles and biological systems: In vitro study of cell toxicity and apoptosis in human keratinocytes (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Interaction between combustion-generated organic nanoparticles and biological systems: In vitro study of cell toxicity and apoptosis in human keratinocytes (Articolo in rivista) (literal)

Anno

• 2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.3109/17435390.2011.579630 (literal)

Alternative label

• Pedata, P; Boccellino, M; La Porta, R; Napolitano, M; Minutolo, P; Sgro, LA; Zei, F; Sannolo, N; Quagliuolo, L (2012)
  Interaction between combustion-generated organic nanoparticles and biological systems: In vitro study of cell toxicity and apoptosis in human keratinocytes
  in Nanotoxicology (Print); Informa Healthcare, New York (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Pedata, P; Boccellino, M; La Porta, R; Napolitano, M; Minutolo, P; Sgro, LA; Zei, F; Sannolo, N; Quagliuolo, L (literal)

Pagina inizio

• 338 (literal)

Pagina fine

• 352 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://informahealthcare.com/doi/abs/10.3109/17435390.2011.579630 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 6 (literal)

Rivista

• Nanotoxicology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR, Inst Res Combust, I-80125 Naples, Italy Univ Naples 2, Dept Expt Med Occupat Med, Naples, Italy Univ Naples 2, Dept Hyg, Naples, Italy Univ Naples 2, Dept Ind Toxicol Sect, Naples, Italy Univ Naples 2, Dept Biochem, Naples, Italy Univ Naples 2, Dept Biophys, Naples, Italy G Pascale Fdn 1, Dept Natl Canc Inst, Naples, Italy Univ Naples Federico II, Dept Chem Engn, Naples, Italy (literal)

Titolo

• Interaction between combustion-generated organic nanoparticles and biological systems: In vitro study of cell toxicity and apoptosis in human keratinocytes (literal)

Abstract

• The purpose of this work was to evaluate the effect of flame-generated nucleation mode particles with an organic carbon structure on growth and apoptosis in immortalized human keratinocytes. In this study, cells were stimulated with nanoparticles collected from flames that produce only nucleation mode particles operating with a fuel: air mixture typical of low-emission combustion systems. Cytotoxicity as a function of particle concentration was monitored by fluorescence-activated cell sorting (FACS) analysis, and apoptosis was observed by FACS using DNA fragmentation and hypodiploidism and confirmed by annexin assay. A dose-dependent reduction in cell viability by apoptosis in incubation periods of 48 and 72 hours was observed with a statistically significant increase in apoptosis over controls for a dose larger than 7 mu g/mL (1.4 mg/cm(2)). The results presented here may be relevant for understanding the association between exposure to traffic-generated particulate pollution and enhanced skin aging reported in epidemiology studies. (literal)

Editore

• Informa Healthcare (Editore)

Prodotto di

• Studio dei meccanismi di formazione e sviluppo di diagnostiche avanzate di inquinanti da processi di combustione (ET.P01.004.001) (Modulo)
• Istituto di ricerche sulla combustione (IRC) (Istituto)

Autore CNR

• PATRIZIA MINUTOLO (Persona)

Insieme di parole chiave

• Keywords of "Interaction between combustion-generated organic nanoparticles and biological systems: In vitro study of cell toxicity and apoptosis in human keratinocytes" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di ricerche sulla combustione (IRC) (Istituto)
• Studio dei meccanismi di formazione e sviluppo di diagnostiche avanzate di inquinanti da processi di combustione (ET.P01.004.001) (Modulo)

Autore CNR di

• PATRIZIA MINUTOLO (Persona)

Editore di

• Informa Healthcare (Editore)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nanotoxicology (Rivista)

Insieme di parole chiave di

• Keywords of "Interaction between combustion-generated organic nanoparticles and biological systems: In vitro study of cell toxicity and apoptosis in human keratinocytes" (Insieme di parole chiave)