Differential requirements for antigen or homeostatic cytokines for proliferation and differentiation of human V gamma 9V delta 2 naive, memory and effector T cell subsets (Articolo in rivista)

Type
Label
  • Differential requirements for antigen or homeostatic cytokines for proliferation and differentiation of human V gamma 9V delta 2 naive, memory and effector T cell subsets (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/eji.200525983 (literal)
Alternative label
  • Caccamo, N ; Meraviglia, S ; Ferlazzo, V ; Angelini, D ); Borsellino, G ; Poccia, F ; Battistini, L ; Dieli, F ; Salerno, A (2005)
    Differential requirements for antigen or homeostatic cytokines for proliferation and differentiation of human V gamma 9V delta 2 naive, memory and effector T cell subsets
    in European Journal of Immunology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Caccamo, N ; Meraviglia, S ; Ferlazzo, V ; Angelini, D ); Borsellino, G ; Poccia, F ; Battistini, L ; Dieli, F ; Salerno, A (literal)
Pagina inizio
  • 1764 (literal)
Pagina fine
  • 1772 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 35 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 6 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. Univ Palermo, Dipartimento Biopatol & Metodol Biomed, I-90134 Palermo, Italy 2. Santa Lucia Fdn, IRCCS, Neuroimmunol Unit, Rome, Italy 3. Ist Nazl Malattie Infett Lazzaro Spallanzani, Rome, Italy 4. CNR, Ist Biomed & Immunol Mol, Palermo, Italy (literal)
Titolo
  • Differential requirements for antigen or homeostatic cytokines for proliferation and differentiation of human V gamma 9V delta 2 naive, memory and effector T cell subsets (literal)
Abstract
  • We have compared four human subsets of V gamma 9V delta 2 T cells, naive (T-naive, CD45RA(+)CD27(+)), central memory (T-CM, CD45RA(-)CD27(+)), effector memory (T-EM, CD45RA(-)CD27(-)) and terminally differentiated (T-EMRA, CD45RA(+)CD27(-)), for their capacity to proliferate and differentiate in response to antigen or homeostatic cytokines. Cytokine responsiveness and IL-15R expression were low in T-naive cells and progressively increased from T-CM to T-EM and T-EMRA cells. In contrast, the capacity to expand in response to antigen or cytokine stimulation showed a reciprocal pattern and was associated with resistance to cell death and Bcl-2 expression. Whereas antigen-stimulated cells acquired a T-CM or T-EM phenotype, IL-15-stimulated cells maintained their phenotype, with the exception of T-CM cells, which expressed CD27 and CD45RA in various combinations. These results, together with ex vivo bromodeoxyuridine incorporation experiments, show that human V gamma 9V delta 2 memory T cells have different proliferation and differentiation potentials in vitro and in vivo and that T-EMRA cells are generated from the T-CM subset upon homeostatic proliferation in the absence of antigen. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it