Role of computed tomography and [F-18] fluorodeoxyglucose positron emission tomography image fusion in conformal radiotherapy of non-small cell lung cancer: A comparison with standard techniques with and without elective nodal irradiation (Articolo in rivista)

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  • Role of computed tomography and [F-18] fluorodeoxyglucose positron emission tomography image fusion in conformal radiotherapy of non-small cell lung cancer: A comparison with standard techniques with and without elective nodal irradiation (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Alternative label
  • Ceresoli, GL (Ceresoli, Giovanni Luca); Cattaneo, GM (Cattaneo, Giovanni Mauro); Castellone, P (Castellone, Pietro); Rizzo, G (Rizzo, Giovanna); Landoni, C (Landoni, Claudio); Gregorc, V (Gregorc, Vanesa); Calandrino, R (Calandrino, Riccardo); Villa, E (Villa, Eugenio); Messa, C (Messa, Cristina); Santoro, A (Santoro, Armando); Fazio, F (Fazio, Ferruccio) (2007)
    Role of computed tomography and [F-18] fluorodeoxyglucose positron emission tomography image fusion in conformal radiotherapy of non-small cell lung cancer: A comparison with standard techniques with and without elective nodal irradiation
    in Tumori (Testo stamp.))
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Ceresoli, GL (Ceresoli, Giovanni Luca); Cattaneo, GM (Cattaneo, Giovanni Mauro); Castellone, P (Castellone, Pietro); Rizzo, G (Rizzo, Giovanna); Landoni, C (Landoni, Claudio); Gregorc, V (Gregorc, Vanesa); Calandrino, R (Calandrino, Riccardo); Villa, E (Villa, Eugenio); Messa, C (Messa, Cristina); Santoro, A (Santoro, Armando); Fazio, F (Fazio, Ferruccio) (literal)
Pagina inizio
  • 88 (literal)
Pagina fine
  • 96 (literal)
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  • 93 (literal)
Rivista
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  • 9 (literal)
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  • 1 (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • 1. Ist Clin Humanitas, Dept Haematol & Oncol, I-20089 Milan, Italy 2. Ist Sci San Raffaele, Dept Oncol, I-20132 Milan, Italy 3. Ist Sci San Raffaele, Dept Phys Med, I-20132 Milan, Italy 4. Univ Naples Federico 2, Dept Phys, Naples, Italy 5. CNR, IBFM, Inst Mol Bioimaging & Physiol, I-20133 Milan, Italy 6. Ist Sci San Raffaele, Dept Nucl Med, I-20132 Milan, Italy 7. Univ Milano Bicocca, Sch Med, Milan, Italy 8. HS Gerardo, Dept Nucl Med, Milan, Italy (literal)
Titolo
  • Role of computed tomography and [F-18] fluorodeoxyglucose positron emission tomography image fusion in conformal radiotherapy of non-small cell lung cancer: A comparison with standard techniques with and without elective nodal irradiation (literal)
Abstract
  • Aims and background. Mediastinal elective node irradiation (ENI) in patients with non-small cell lung cancer candidate to radical radiotherapy is controversial. In this study, the impact of co-registered [F-18]fluorodeoxyglucose-positron emission tomography (PET) and standard computed tomography (CT) on definition of target volumes and toxicity parameters was evaluated, by comparison with standard CT-based simulation with and without ENI. Methods: CT-based gross tumor volume (GTV(CT)) was first contoured by a single observer without knowledge of PET results. Subsequently, the integrated GTV based on PET/CT coregistered images (GTV(PET/CT)) was defined. Each patient was planned according to three different treatment techniques: 1) radiotherapy with ENI using the CT data set alone (ENI plan); 2) radiotherapy without ENI using the CT data set alone (no ENI plan); 3) radiotherapy without ENI using PET/CT fusion data set (PET plan). Rival plans were compared for each patient with respect to dose to the normal tissues (spinal cord, healthy lungs, heart and esophagus). Results: The addition of PET-modified TNM staging in 10/21 enrolled patients (48%); 3/21 were shifted to palliative treatment due to detection of metastatic disease or large tumor not amenable to high-dose radiotherapy. In 7/18 (39%) patients treated with radical radiotherapy, a significant (>= 25%) change in volume between GTVCT and GTV(PET/CT) was observed. For all the organs at risk, ENI plans had dose values significantly greater than no-ENI and PET plans. Comparing no ENI and PET plans, no statistically significant difference was observed, except for maximum point dose to the spinal cord D-max, which was significantly lower in PET plans. Notably, even in patients in whom PET/CT planning resulted in an increased GTV, toxicity parameters were fairly acceptable, and always more favorable than with ENI plans (literal)
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