The dodecameric ferritin from Listeria innocua contains a novel intersubunit iron-binding site (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• The dodecameric ferritin from Listeria innocua contains a novel intersubunit iron-binding site (Articolo in rivista) (literal)

Anno

• 2000-01-01T00:00:00+01:00 (literal)

Alternative label

• Ilari, A ; Stefanini, S; Chiancone, E ; Tsernoglou, D (2000)
  The dodecameric ferritin from Listeria innocua contains a novel intersubunit iron-binding site
  in Nature structural biology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ilari, A ; Stefanini, S; Chiancone, E ; Tsernoglou, D (literal)

Pagina inizio

• 38 (literal)

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• 7 (literal)

Rivista

• Nature structural biology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Univ La Sapienza, Dept Biochem Sci A Rossi Fanelli, CNR, Ctr Mol Biol, I-00185 Rome, Italy (literal)

Titolo

• The dodecameric ferritin from Listeria innocua contains a novel intersubunit iron-binding site (literal)

Abstract

• Ferritin is characterized by a highly conserved architecture that comprises 24 subunits assembled into a spherical cage with 432 symmetry. The only known exception is the dodecameric ferritin from Listeria innocua. The structure of Listeria ferritin has been determined to a resolution of 2.35 Angstrom by molecular replacement, using as a search model the structure of Dps from Escherichia coli, The Listeria 12-mer is endowed with 23 symmetry and displays the functionally relevant structural features of the ferritin 24-mer, namely the negatively charged channels along the three-fold symmetry axes that serve for iron entry into the cavity and a negatively charged internal cavity for iron deposition. The electron density map shows 12 iron ions on the inner surface of the hollow core, at the interface between monomers related by two-fold axes. Analysis of the nature and stereochemistry of the iron-binding ligands reveals strong similarities with known ferroxidase sites. The L. innocua ferritin site, however, is the first described so far that has ligands belonging to two different subunits and is not contained within a four-helix bundle. (literal)

Prodotto di

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Biologia strutturale e bioinformatica: struttura-funzione, dinamica e riconoscimento in proteine (SV.P14.008.001) (Modulo)

Autore CNR

• EMILIA CHIANCONE (Unità di personale esterno)
• ANDREA ILARI (Unità di personale interno)

Incoming links:

Prodotto

• Institute of molecular biology and pathology (IBPM) (Istituto)
• Biologia strutturale e bioinformatica: struttura-funzione, dinamica e riconoscimento in proteine (SV.P14.008.001) (Modulo)

Autore CNR di

• EMILIA CHIANCONE (Unità di personale esterno)
• ANDREA ILARI (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nature structural biology (Rivista)