http://www.cnr.it/ontology/cnr/individuo/prodotto/ID18615

Stochastic fluctuations of the synaptic function (Articolo in rivista)

Type

Label

Stochastic fluctuations of the synaptic function (Articolo in rivista) (literal)

Anno

Alternative label

Ventriglia F. 1, Di Maio V. 2 (2002)
Stochastic fluctuations of the synaptic function
in Biosystems (Amst. Print)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Pagina inizio

Pagina fine

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

Rivista

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

Biosystems - ISSN: 0303-2647, Total Cites: 806, ImpactFactor: 0.846, ImmediacyIndex: 0.112, Articles in 2002: 80, Citing Half life: 6.5, Ranking basato su Impact Factor: 32 su 62 riviste \"Biology\" (literal)

Note

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1. Istituto di Cibernetica E. Caianiello, CNR, Pozzuoli, Naples, Italy 2. Istituto di Cibernetica E. Caianiello, CNR, Pozzuoli, Naples, Italy (literal)

Titolo

Abstract

The peak amplitudes of the quantal Excitatory Post Synaptic Currents in single hippocampal synapses show a large variability. Here, we present the results of a mathematical, computational investigation on the main sources of this variability. A detailed description of the synaptic cleft, rigorously based on empirically-derived parameters, was used. By using a Brownian motion model of neurotransmitter molecule diffusion, quantal EPSCs were computed by a simple kinetic schema of AMPA receptor dynamics. Our results show that the lack of saturation of AMPA receptors obtained in these conditions, combined with stochastic variations in basic presynaptic elements, such as the vesicle volume, the vesicle docking position, and the vesicle neurotransmitter concentration can explain almost the entire range of EPSC variability experimentally observed. (literal)

Prodotto di