Synaptic fusion pore structure and AMPA receptor activation investigated by Brownian simulation of glutamate diffusion (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Synaptic fusion pore structure and AMPA receptor activation investigated by Brownian simulation of glutamate diffusion (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Ventriglia F.; Di Maio V. (2003)
  Synaptic fusion pore structure and AMPA receptor activation investigated by Brownian simulation of glutamate diffusion
  in Biological cybernetics
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ventriglia F.; Di Maio V. (literal)

Pagina inizio

• 201 (literal)

Pagina fine

• 209 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Impact Factor e altri parametri valutati per l'anno 2002, non essendo disponibili i dati 2003 (literal)

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• 88 (literal)

Rivista

• Biological cybernetics (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• Biological Cybernetics - ISSN: 0340-1200, Total Cites: 3153, ImpactFactor(2002): 1.511, ImmediacyIndex: 0.354, Articles in 2002: 79, Citing Half life: >10.0, Ranking basato su Imp.Factor: 3 su 18 riviste .\"Comp. Sci. And Cyber.\", 125/197 \"Neurosciences\" (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Istituto di Cibernetica E. Caianiello, CNR, Pozzuoli, Naples, Italy 2. (In Pensione) Istituto di Cibernetica E. Caianiello, CNR, Pozzuoli, Naples, Italy (literal)

Titolo

• Synaptic fusion pore structure and AMPA receptor activation investigated by Brownian simulation of glutamate diffusion (literal)

Abstract

• The rising phase of fast, AMPA-mediated Excitatory Post Synaptic Currents (EPSCs) has a primary role in the computational ability of neurons. The structure and radial expansion velocity of the fusion pore between the vesicle and the presynaptic membrane could be important factors in determining the time course of the EPSC. We have used a Brownian simulation model for glutamate neurotransmitter diffusion to test two hypotheses on the fusion pore structure, namely, the proteinaceous pore and the purely lipidic pore. Three more hypotheses on the radial expansion velocity were also tested. The rising phases of the EPSC, computed under various conditions, were compared with experimental data from the literature. Our present results show that a proteinaceous fusion pore should produce a more marked foot at the beginning of the rising phase of the EPSC. They also confirm the hypothesis that the structure of the fusion pore and its radial expansion velocity play significant roles in shaping the fast EPSC time course. (literal)

Prodotto di

• Istituto di cibernetica \"Edoardo Caianiello\" (ISASI) (Istituto)

Autore CNR

• VITO DI MAIO (Persona)
• FRANCESCO VENTRIGLIA (Persona)

Insieme di parole chiave

• Keywords of "Synaptic fusion pore structure and AMPA receptor activation investigated by Brownian simulation of glutamate diffusion" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• FRANCESCO VENTRIGLIA (Persona)
• VITO DI MAIO (Persona)

Prodotto

• Istituto di cibernetica \"Edoardo Caianiello\" (ISASI) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biological cybernetics (Rivista)

Insieme di parole chiave di

• Keywords of "Synaptic fusion pore structure and AMPA receptor activation investigated by Brownian simulation of glutamate diffusion" (Insieme di parole chiave)