The weaver mutant mouse: a model to study the ontogeny of dopamine transmission systems and their role in drug addiction (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The weaver mutant mouse: a model to study the ontogeny of dopamine transmission systems and their role in drug addiction (Articolo in rivista) (literal)

Anno

• 2001-01-01T00:00:00+01:00 (literal)

Alternative label

• Maharajan P. 1, Maharajan V. 2, Ravagnan G. 3,Paino G. 4 (2001)
  The weaver mutant mouse: a model to study the ontogeny of dopamine transmission systems and their role in drug addiction
  in Progress in neurobiology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Maharajan P. 1, Maharajan V. 2, Ravagnan G. 3,Paino G. 4 (literal)

Pagina inizio

• 269 (literal)

Pagina fine

• 276 (literal)

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• 64-3 (literal)

Rivista

• Progress in neurobiology (Rivista)

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• Progress in Neurobiology - ISSN: 0301-0082, Total Cites: 5926, ImpactFactor: 9.377, ImmediacyIndex: 1.629, Articles in 2001: 62, Citing Half life: 5.4, Ranking basato su Impact Factor: 10 su 198 riviste \"Neurosciences\" (literal)

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• Articolo di review con informazioni per la conduzione di esperimenti sulla tossicodipendenza per comprendere il meccanismo di azione di sostanze che agiscono sul sistema dopaminergico. (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. BioGem, Villa Comunale, Naples, Italy 2. Istituto di Cibernetica E. Caianiello, CNR, Pozzuoli, Napoli, Italy 3. Institute od Experimental Medicine, CNR, Rome, Italy 4. Dept. Structure, Function and Biological Technology, Univ. Naples Federico II, Naples, Italy (literal)

Titolo

• The weaver mutant mouse: a model to study the ontogeny of dopamine transmission systems and their role in drug addiction (literal)

Abstract

• Dopaminergic neurons and their projection-systems are important in some fundamental human activities like locomotion, feeding and sex, essential for survival and procreation, and are relevant to pathologies like Parkinson's disease and drug abuse. Three main dopaminergic projection-systems, namely the nigrostriatal, mesocortical and mesolimbic pathways are the major targets of the neuropharmacological actions of psychomotor stimulants such as cocaine and amphetamine. Studies on knockout mice for dopamine or its receptors provide substantial information but fail to reveal the role of individual dopaminergic projection-systems. Mutant animals with defects specific to one or more projection-systems might be useful for studying the role of individual dopaminergic projection-systems. We propose the weaver mutant mouse, with a defective nigrostriatal dopaminergic projection-system and dopamine depletion in the dorsal striatum but with intact mesocorticolimbic projection-systems, as a suitable model to study the role of individual dopaminergic systems in diverse biological processes including Parkinson's disease and drug abuse. (literal)

Prodotto di

• Istituto di Scienze Applicate e Sistemi Intelligenti \"Eduardo Caianiello\" (ISASI) (Istituto)

Autore CNR

• VEERAMANI MAHARAJAN (Unità di personale interno)

Insieme di parole chiave

• Keywords of "The weaver mutant mouse: a model to study the ontogeny of dopamine transmission systems and their role in drug addiction" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di Scienze Applicate e Sistemi Intelligenti \"Eduardo Caianiello\" (ISASI) (Istituto)

Autore CNR di

• VEERAMANI MAHARAJAN (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Progress in neurobiology (Rivista)

Insieme di parole chiave di

• Keywords of "The weaver mutant mouse: a model to study the ontogeny of dopamine transmission systems and their role in drug addiction" (Insieme di parole chiave)