The interplay between the master transcription factor PU.1 and miR-424 regulates human monocytic differentiation (Articolo in rivista)

Type
Label
  • The interplay between the master transcription factor PU.1 and miR-424 regulates human monocytic differentiation (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1073/pnas.0706963104 (literal)
Alternative label
  • Rosa A.; Ballarino M.; Sorrentino A.; Sthandier O.; De Angelis F.G.; Marchioni M.; Guarini A.; Fatica A.; Peschle C.; Bozzoni I. (2007)
    The interplay between the master transcription factor PU.1 and miR-424 regulates human monocytic differentiation
    in Proceedings of the National Academy of Sciences of the United States of America
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Rosa A.; Ballarino M.; Sorrentino A.; Sthandier O.; De Angelis F.G.; Marchioni M.; Guarini A.; Fatica A.; Peschle C.; Bozzoni I. (literal)
Pagina inizio
  • 19849 (literal)
Pagina fine
  • 19854 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 104 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute Pasteur Cenci-Bolognetti, Department of Genetics and Molecular Biology, Institute of Molecular Biology and Pathology, and Department of Cellular Biotechnologies and Hematology, University of Rome \"La Sapienza\", Rome, Italy. (literal)
Titolo
  • The interplay between the master transcription factor PU.1 and miR-424 regulates human monocytic differentiation (literal)
Abstract
  • We describe a pathway by which the master transcription factor PU.1 regulates human monocyte/macrophage differentiation. This includes miR-424 and the transcriptional factor NFI-A. We show that PU.1 and these two components are interlinked in a finely tuned temporal and regulatory circuitry: PU.1 activates the transcription of miR-424, and this up-regulation is involved in stimulating monocyte differentiation through miR-424-dependent translational repression of NFI-A. In turn, the decrease in NFI-A levels is important for the activation of differentiation-specific genes such as M-CSFr. In line with these data, both RNAi against NFI-A and ectopic expression of miR-424 in precursor cells enhance monocytic differentiation, whereas the ectopic expression of NFI-A has an opposite effect. The interplay among these three components was demonstrated in myeloid cell lines as well as in human CD34+ differentiation. These data point to the important role of miR-424 and NFI-A in controlling the monocyte/macrophage differentiation program. (literal)
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