Synthesis, Characterization, and Biological Evaluation of [188Re(N)(cys~)(PNP)]+/0 mixedligand complexes as prototypes for the development of 188Re(N)-based target-specific radiopharmaceuticals (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Synthesis, Characterization, and Biological Evaluation of [188Re(N)(cys~)(PNP)]+/0 mixedligand complexes as prototypes for the development of 188Re(N)-based target-specific radiopharmaceuticals (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Alternative label

• Thieme, S.; Agostini, S.; Bergmann, R.; Pietzsch, J.; Pietzsch, H.J.; Carta, D.; Salvarese, N.; Refosco, F.; Bolzati, C. (2010)
  Synthesis, Characterization, and Biological Evaluation of [188Re(N)(cys~)(PNP)]+/0 mixedligand complexes as prototypes for the development of 188Re(N)-based target-specific radiopharmaceuticals
  in Nuclear medicine and biology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Thieme, S.; Agostini, S.; Bergmann, R.; Pietzsch, J.; Pietzsch, H.J.; Carta, D.; Salvarese, N.; Refosco, F.; Bolzati, C. (literal)

Rivista

• Nuclear medicine and biology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• Articles in Press Received 7 July 2010; received in revised form 24 September 2010; accepted 29 September 2010. published online 03 December 2010. (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• (1,3-5) Institute of Radiopharmacy, Forschungszentrum Dresden Rossendorf, Dresden, Germany (2,6,7) Department of Pharmaceutical Sciences, University of Padua, Padova, Italy (8,9) ICIS-CNR, Padova, Italy (literal)

Titolo

• Synthesis, Characterization, and Biological Evaluation of [188Re(N)(cys~)(PNP)]+/0 mixedligand complexes as prototypes for the development of 188Re(N)-based target-specific radiopharmaceuticals (literal)

Abstract

• We report on an efficient procedure for the preparation of [188Re(N)(PNP)] - based complexes (where PNP is diphosphinoamine) useful in the development of target-specific radiopharmaceuticals. The radiochemical yield of the compounds was optimized considering such reaction parameters as nature of the nitrido nitrogen donor, reaction times and pH level. The chemical identity of the 188Re agents was determined by high-performance liquid chromatography comparison with the corresponding well-characterized cold Re compounds. 188Re(N) mixed compounds have been evaluated with regard to stability toward transchelation with GSH and degradation by serum enzymes. The clearance of selected radiocompounds from normal tissues and their in vivo stability were evaluated in rats by biodistribution and imaging studies. .................... (literal)

Prodotto di

• Sintesi e valutazione biologica di nuovi complessi metallici per il \"targeting molecolare\" (PM.P01.019.004) (Modulo)
• Istituto di chimica inorganica e delle superfici (ICIS) (Istituto)
• Progettazione e sintesi di sistemi molecolari inorganici per diagnosi e terapia (PM.P01.019.002) (Modulo)
• Progettazione e sintesi di leganti fosfinici funzionalizzati e bifunzionali biologicamente attivi (PM.P01.019.003) (Modulo)

Autore CNR

• CRISTINA BOLZATI (Unità di personale interno)
• FIORENZO REFOSCO (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Synthesis, Characterization, and Biological Evaluation of [188Re(N)(cys~)(PNP)]+/0 mixedligand complexes as prototypes for the development of 188Re(N)-based target-specific radiopharmaceuticals" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di chimica inorganica e delle superfici (ICIS) (Istituto)
• Progettazione e sintesi di leganti fosfinici funzionalizzati e bifunzionali biologicamente attivi (PM.P01.019.003) (Modulo)
• Progettazione e sintesi di sistemi molecolari inorganici per diagnosi e terapia (PM.P01.019.002) (Modulo)
• Sintesi e valutazione biologica di nuovi complessi metallici per il \"targeting molecolare\" (PM.P01.019.004) (Modulo)

Autore CNR di

• CRISTINA BOLZATI (Unità di personale interno)
• FIORENZO REFOSCO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nuclear medicine and biology (Rivista)

Insieme di parole chiave di

• Parole chiave di "Synthesis, Characterization, and Biological Evaluation of [188Re(N)(cys~)(PNP)]+/0 mixedligand complexes as prototypes for the development of 188Re(N)-based target-specific radiopharmaceuticals" (Insieme di parole chiave)