A role for BARS at the fission step of COPI vesicle formation from Golgi membrane (Articolo in rivista)

Type
Label
  • A role for BARS at the fission step of COPI vesicle formation from Golgi membrane (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/sj.emboj.7600873 (literal)
Alternative label
  • Yang J.S.; Lee S.Y.; Spanò S.; Gad H.; Zhang L.; Nie Z.; Bonazzi M.; Corda D.; Luini A.; Hsu V.W. (2005)
    A role for BARS at the fission step of COPI vesicle formation from Golgi membrane
    in EMBO journal (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Yang J.S.; Lee S.Y.; Spanò S.; Gad H.; Zhang L.; Nie Z.; Bonazzi M.; Corda D.; Luini A.; Hsu V.W. (literal)
Pagina inizio
  • 4133 (literal)
Pagina fine
  • 4143 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 24 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 23 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Brigham & Womens Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Med, Boston, MA USA Consorzio Mario Negri Sud, Dept Cell Biol & Oncol, Chieti, Italy NCI, Cellular Oncol Lab, Bethesda, MD 20892 USA (literal)
Titolo
  • A role for BARS at the fission step of COPI vesicle formation from Golgi membrane (literal)
Abstract
  • The core complex of Coat Protein I (COPI), known as coatomer, is sufficient to induce coated vesicular-like structures from liposomal membrane. In the context of biological Golgi membrane, both palmitoyl-coenzyme A (p-coA) and ARFGAP1, a GTPase-activating protein (GAP) for ADP-Ribosylation Factor 1, also participate in vesicle formation, but how their roles may be linked remains unknown. Moreover, whether COPI vesicle formation from Golgi membrane requires additional factors also remains unclear. We now show that Brefeldin-A ADP-Ribosylated Substrate (BARS) plays a critical role in the fission step of COPI vesicle formation from Golgi membrane. This role of BARS requires its interaction with ARFGAP1, which is in turn regulated oppositely by p-coA and nicotinamide adenine dinucleotide, which act as cofactors of BARS. Our findings not only identify a new factor needed for COPI vesicle formation from Golgi membrane but also reveal a surprising mechanism by which the roles of p-coA and GAP are linked in this process. (literal)
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