Quantification of subendocardial and subepicardial blood flow using O-15-labeled water and PET: Experimental validation (Articolo in rivista)

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  • Quantification of subendocardial and subepicardial blood flow using O-15-labeled water and PET: Experimental validation (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Rimoldi O, Schäfers KP, Boellaard R, Turkheimer F, Stegger L, Law MP, Lammerstma AA, Camici PG (2006)
    Quantification of subendocardial and subepicardial blood flow using O-15-labeled water and PET: Experimental validation
    in The Journal of nuclear medicine (1978)
    (literal)
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  • Rimoldi O, Schäfers KP, Boellaard R, Turkheimer F, Stegger L, Law MP, Lammerstma AA, Camici PG (literal)
Pagina inizio
  • 163 (literal)
Pagina fine
  • 172 (literal)
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  • 47 (literal)
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  • 1 (literal)
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  • PubMe (literal)
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  • Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, United Kingdom (literal)
Titolo
  • Quantification of subendocardial and subepicardial blood flow using O-15-labeled water and PET: Experimental validation (literal)
Abstract
  • The purpose of this study was to assess the feasibility and accuracy of quantifying subendocardial and subepicardial myocardial blood flow (MBF) and the relative coronary flow reserves (CFR) using (15)O-labeled water (H(2)(15)O) and 3-dimensional-only PET. METHODS: Eight pigs were scanned with H(2)(15)O and (15)O-labeled carbon monoxide (C(15)O) after partially occluding the circumflex (n = 3) or the left anterior descending (n = 5) coronary artery, both at rest and during hyperemia induced by intravenous dipyridamole. Radioactive microspheres were injected during each of the H(2)(15)O scans. RESULTS: In a total of 256 paired measurements of MBF, ranging from 0.30 to 4.46 mL.g(-1).min(-1), microsphere and PET MBF were fairly well correlated. The mean difference between the 2 methods was -0.01 +/- 0.52 mL.g(-1).min(-1) with 95% of the differences lying between the limits of agreement of -1.02 and 1.01 mL.g(-1).min(-1). CFR was significantly reduced (P < 0.05) in the ischemic subendocardium (PET = 1.12 +/- 0.45; microspheres = 1.09 +/- 0.50; P = 0.86) and subepicardium (PET = 1.2 +/- 0.35; microspheres = 1.32 +/- 0.5; P = 0.39) in comparison with remote subendocardium (PET = 1.7 +/- 0.62; microspheres = 1.64 +/- 0.61; P = 0.68) and subepicardium (PET = 1.79 +/- 0.73; microspheres = 2.19 +/- 0.86; P = 0.06). CONCLUSION: Dynamic measurements using H(2)(15)O and a 3-dimensional-only PET tomograph allow regional estimates of the transmural distribution of MBF over a wide flow range, although transmural flow differences were underestimated because of the partial-volume effect. PET subendocardial and subepicardial CFR were in good agreement with the microsphere values. (literal)
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