Supported Imprinted Nanospheres for a Selective Recognition of Cholesterol (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Supported Imprinted Nanospheres for a Selective Recognition of Cholesterol (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.bios.2005.12.027 (literal)

Alternative label

• CIARDELLI G.; BORRELLI C; SILVESTRI D; CRISTALLINI C; BARBANI N; GIUSTI P (2006)
  Supported Imprinted Nanospheres for a Selective Recognition of Cholesterol
  in Biosensors & bioelectronics
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• CIARDELLI G.; BORRELLI C; SILVESTRI D; CRISTALLINI C; BARBANI N; GIUSTI P (literal)

Pagina inizio

• 2329 (literal)

Pagina fine

• 2338 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 21 (literal)

Rivista

• Biosensors & bioelectronics (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 10 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Chemical Engineering, Industrial Chemistry and Material Science, University of Pisa, via Diotisalvi 2, 56126 Pisa, Italy C.N.R. Institute for Composite and Biomedical Materials, c.o Dept. Chemical Engineering, University of Pisa, Italy Department of Mechanics, Politecnico of Turin, corso Duca degli Abruzzi 24 Turin, Italy (literal)

Titolo

• Supported Imprinted Nanospheres for a Selective Recognition of Cholesterol (literal)

Abstract

• The preparation of innovative polymeric systems using molecular imprinting technology for application in extracorporeal blood purification is described. Membranes based on a methylmethacrylate-co-acrylic acid copolymer, produced through the phase inversion method, were modified introducing into their structure specific binding sites for cholesterol molecule by adding molecularly imprinted nanoparticles in the membrane matrix. Membranes prepared are intended to selectively remove cholesterol from the blood by using interactions at a molecular level, between the membrane/nanoparticles devices and the template, created during the preparation of polymers. Three polymeric systems in form of nanoparticles were prepared differing in the polymerisation solvent (a mixture of acetonitrile and ethanol (1:1) or pure ethanol), and the molar ratio between the functional monomer and the cross-linker (2.3:1 and 1:1). Two out of three of the prepared polymers showed a very good template rebinding capacity both in phosphate buffer solution (pH 6.9) and in ethanol. In particular the nanoparticles rebound 115.4 mg cholesterol/g polymer in buffer solution, and 57 mg cholesterol/g polymer in ethanol. The deposition of the nanoparticles on the surface of the phase inversion membranes produced devices with interesting rebinding performances towards cholesterol in buffer solution: a specific recognition of 14.09 mg cholesterol/g system (membrane and nanoparticles)was detected, indicating maintained binding capacity of supported particles as well (literal)

Prodotto di

• Institute for chemical and physical processes (IPCF) (Istituto)
• Progettazione, preparazione e proprietà di materiali polimerici multifasici e/o funzionali a struttura e composizione modulabile (MD.P01.026.001) (Modulo)

Autore CNR

• GIANLUCA CIARDELLI (Unità di personale esterno)

Incoming links:

Prodotto

• Institute for chemical and physical processes (IPCF) (Istituto)
• Progettazione, preparazione e proprietà di materiali polimerici multifasici e/o funzionali a struttura e composizione modulabile (MD.P01.026.001) (Modulo)

Autore CNR di

• GIANLUCA CIARDELLI (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biosensors & bioelectronics (Rivista)