http://www.cnr.it/ontology/cnr/individuo/prodotto/ID184352

Vascular endothelial growth factor (VEGF) and other common tissue prognostic indicators in breast cancer: A case-control study (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Vascular endothelial growth factor (VEGF) and other common tissue prognostic indicators in breast cancer: A case-control study (Articolo in rivista) (literal)

Anno

2004-01-01T00:00:00+01:00 (literal)

Alternative label

A. Nicolini1; D. Campani2; P. Miccoli3; C. Spinelli3; A. Carpi4; M. Menicagli2; P. Ferrari1; G. Gadducci4; G. Rossi5; M. Fini6; G. Giavaresi6; V. Bonazzi7; R. Giardino6 (2004)
Vascular endothelial growth factor (VEGF) and other common tissue prognostic indicators in breast cancer: A case-control study
in The International Journal of Biological Markers (Testo stamp.); Wichtig Editore, Milan (Italia)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

A. Nicolini1; D. Campani2; P. Miccoli3; C. Spinelli3; A. Carpi4; M. Menicagli2; P. Ferrari1; G. Gadducci4; G. Rossi5; M. Fini6; G. Giavaresi6; V. Bonazzi7; R. Giardino6 (literal)

Pagina inizio

275 (literal)

Pagina fine

281 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

19 (literal)

Rivista

?The ?International Journal of Biological Markers (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

4 (literal)

Note

ubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1Department of Internal Medicine, 2Department of Oncology, 3Department of Surgery, 4Department of Reproduction and Aging, University of Pisa 5Unit of Epidemiology and Biostatistics, Institute of Clinical Physiology, National Research Council (CNR), Pisa 6Department of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopedic Institute, Bologna 7Associazione Nazionale Tumori (ANT), Bologna - Italy (literal)

Titolo

Vascular endothelial growth factor (VEGF) and other common tissue prognostic indicators in breast cancer: A case-control study (literal)

Abstract

VEGF is a specific mitogen and survival factor for endothelial cells and a key promoter of angiogenesis in physiological and pathological conditions. Nevertheless, VEGF tissue evaluation in cancer patients as a prognostic factor compared to the conventional histological and biological parameters is still controversial. In this case-control study, tissue VEGF was retrospectively determined by immunohistochemistry and related to T, N, ER, PgR, c-erbB-2, p53, MIB-1 and cyclin D1 in 129 breast cancer patients. Seventy-four of these patients had developed distant metastases postoperatively. The remaining 55 patients had remained disease-free >10 years after surgery. In 17 (13%) of the 129 patients (six with distant metastases and eleven disease-free) tissue and plasma VEGF were concomitantly evaluated. In univariate analysis no significant differences in VEGF and tumor size were found between metastatic and disease-free patients, whereas there were significant differences in N, ER, PgR, c-erbB-2, p53, MIB-1 and cyclin D1 (p ranging from 0.001 to 0.0001). In multivariate analysis VEGF showed less significance than N, ER, c-erbB-2, MIB-1 and cyclin D1 (p=0.012, p=0.007, p=0.005, p=0.005, p=0.002 and p=0.001, respectively). VEGF was a significant unfavorable prognostic indicator only in the N+ subset (p=0.015), while ER (p=0.05 and p=0.021) and MIB-1 (p=0.031 and p=0.022) were significant in both the N+ and N- subgroups. In multivariate analysis in the 74 metastatic cases VEGF did not show any significance in relation to disease-free interval and overall survival from the time of mastectomy and from the time of relapse, whereas N and PgR did (p ranging from 0.018 to 0.001). In conclusion, tissue VEGF does not seem a suitable candidate to replace conventional histological and other common biological prognostic factors in breast cancer. (literal)

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